Life Extension Technologies

Higher intake of methyl adaptogen foods, such as turmeric, green tea, and berries, was associated with reduced epigenetic age in middle-aged men, according to a secondary analysis of the MDLS trial. These findings support the potential role of specific dietary polyphenols in modulating biological aging, though further research in larger and more diverse populations is needed.

New research highlights a possible link between microplastics in ultra-processed foods and rising rates of depression, anxiety, and sleep problems. Experts call for urgent investigation as microplastic accumulation in the human brain increases alongside ultra-processed food intake.

In a groundbreaking development that could revolutionize the therapeutic landscape for glioblastoma, researchers have unveiled a novel mechanism by which androgen receptor inhibition markedly sensitizes glioblastoma stem cells (GSCs) to temozolomide (TMZ), the current frontline chemotherapeutic agent for this aggressive brain tumor. This breakthrough not only sheds light on the intricate molecular interplay within glioblastoma […]

Vitamin D supplements may help prevent the loss of telomeres, DNA sequences that shrink with aging, a large study shows. But the health effects aren’t yet clear

As desktop 3D printing technology becomes increasingly ubiquitous in homes, schools, and small businesses, questions about its safety and environmental impact have escalated dramatically. A new comprehensive review published in the Journal of Exposure Science & Environmental Epidemiology by Baguley, Evans, Bard, and colleagues sheds critical light on the volatile organic compounds (VOCs) emitted during […]

In new research, scientists aimed to identify dietary components -- such as green tea, oolong tea, turmeric, rosemary, garlic, berries -- associated with epigenetic age change. The post Study: Consuming Methyl Adaptogen-Rich Foods May Reduce Markers of Epigenetic Aging appeared first on Sci.News: Breaking Science News.

Results from the VITAL randomized controlled trial reveal that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging and are linked to the development of certain diseases.

In the murky waters near Mexico City lives a remarkable creature known as the axolotl, a salamander famous for its extraordinary ability to regenerate lost limbs with astonishing precision. These amphibians inhabit an environment fraught with peril, including aggressive and cannibalistic neighbors that frequently result in limb loss. Despite this constant threat, axolotls are capable […]

Millions of people are affected by chronic dry mouth, or xerostomia, an agonizing side effect of damaged salivary glands. While chemotherapy and radiation treatment for head and neck cancer are the most common causes of this, aging, certain medications and other factors, including diabetes, stroke, Alzheimer's disease and HIV/AIDS, can also cause chronic dry mouth. Currently, there is no cure for it.

One of the challenges inherent in developing an industry of medical development aimed at the treatment of aging is that present regulatory structure and investment culture actively discourage any attempt to quantify effects on life span. While aging clocks are interesting, they cannot yet be relied upon, and no-one is willing to fund the lengthy studies needed to assess the effects of any given therapy on long term health the old-fashioned way, by waiting and watching. Aging is not yet considered a treatable medical condition by regulators, and so developers are forced by investors into optimizing their approaches to therapy for specific age-related conditions, as that is the fastest path to market. The XPRIZE Healthspan competition aims to encourage more efforts to assess effects on […]

A collaborative team of researchers from Children's Hospital of Philadelphia (CHOP) found that hematopoietic stem cell transplantation (HSCT) is a highly effective method for treating patients with monogenic inflammatory bowel disease (IBD), a more severe form of the illness usually affecting younger patients. More than 90% of patients achieved sustained medication-free remission.

In a recent study, researchers investigated how restricting dietary methionine and inhibiting the tyrosine degradation pathway affects healthspan in aged mice. While […]

Epigenetic lineage tracing offers insight into hematopoietic complexity and its gradual decline with age – without genetic engineering. As interest … Continue reading "Clonal drift in aging blood tracked with natural barcodes" The post Clonal drift in aging blood tracked with natural barcodes appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

Two of the traits that set modern humans apart from non-human primates are taller stature and a higher basal metabolic rate. Publishing in Cell Genomics, researchers have identified a genetic variant that contributed to the co-evolution of these traits. This mutation seems to help people grow taller—especially when they consume a lot of meat.

Consuming high-quality carbohydrates and dietary fiber in midlife was tied to a 6% to 37% greater likelihood of healthy aging in women, according to a study published in JAMA Network Open.In contrast, refined carbohydrate consumption reduced this likelihood by about 13%.“The favorable associations of dietary fiber beyond chronic disease prevention, specifically the link absence of physical function limitations or memory concerns, were surprising,” Andres V. Ardisson Korat, ScD, a scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, told

Companies to collaborate on new Abu Dhabi drug development hub with a focus on therapeutics designed to ‘extend healthy lifespan.’ … Continue reading "Juvenescence lands $76m led by Abu Dhabi healthcare giant M42" The post Juvenescence lands $76m led by Abu Dhabi healthcare giant M42 appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

Regeneron’s $256 million acquisition marks a potentially transformative moment in the genetic data-driven drug discovery landscape. Regeneron, already a leader … Continue reading "Regeneron’s acquisition of 23andMe: A genomic power shift?" The post Regeneron’s acquisition of 23andMe: A genomic power shift? appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

Experts called for a shift in how clinicians define success in treating obesity in older adults.

Teens worldwide are moving away from alcohol and cigarettes, but are facing increasing obesity and mental health issues, a new Lancet report reveals.

When Page Campbell's doctor recommended she try an injectable prescription drug called Wegovy to lose weight before scheduling bariatric surgery, she readily agreed.

The authors of this open access paper provide an overview of two viewpoints on the onset and progression of neurodegenerative conditions. The biochemistry of the brain is exceptionally complex, and its dysfunction is also complex. It is clear that the aggregation of a few forms of altered protein is important in neurodegeneration, but exactly how and why it is important remains an active area of research. There are points of consensus, points of debate, and this landscape shifts over time as new evidence emerges. The absence of curative therapies for neurodegenerative conditions is a symptom of the inability to determine the critical mechanisms driving dysfunction, distinguishing them from the many interacting consequences of those mechanisms and other changes associated with degenerative aging. Neurodegenerative diseases, such […]

One of the tasks in which machine learning and related techniques excel is finding patterns in very large data sets and extrapolating those patterns to predict as yet undiscovered members. The outcome of combinations of known small molecule drugs and drug candidates is one such data set. There is very little known in certainty about polypharmacology, as research and development groups operate under incentives that strongly discourage assessment of combination treatments. Where researchers have looked into combinations of small molecules in the context of slowing aging, they have found that the typical outcome is that any two compounds that individually alter metabolism to modestly slow aging produce no benefit or a mild harm when combined. This is a vast space of possibilities, little concrete knowledge, […]

Over 1 year of taking the medication, women see a modest decline in waist circumference and body roundness.

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Altos Labs, the massive but still relatively secretive $3 billion biotech, has forged a small acquisition of a startup seeking to reverse aging. Altos, led by industry stalwarts Hal Barron and Hans ...

Historic surgery opens the door for improved treatment of non-functioning bladders. Continue reading World’s first-ever human bladder transplant on Tech Explorist.

Aging is a multifaceted process driven by interconnected biological mechanisms, among which genomic instability and telomere attrition stand as primary hallmarks.

Researchers examined the heritability of body mass index (BMI), highlighting that genetics and the gut microbiome both play major roles in obesity risk. The review emphasizes that maternal microbiome transmission and family environment may help explain “missing heritability” beyond known genetic factors.

Discover how osteopathic manipulation can help active adults maintain mobility, prevent injuries, and enhance performance without disrupting your fitness routine. This comprehensive guide explores how addressing joint restrictions, fascial tension, and movement patterns can resolve persistent discomfort and improve recovery between workouts. Learn why osteopathic care offers a valuable approach to movement longevity for adults who want to stay active and pain-free at any age. The post The Athletic Edge: How Osteopathic Manipulation Helps Active Adults Move Better appeared first on Longevity Care Clinic.

Discover how acupuncture and E-Stim offer more than stress relief for active adults seeking sustainable pain management. Learn why this ancient practice combined with modern technology may help address chronic pain and inflammation at the source. Experience the unexpected benefits of acupuncture beyond pain relief, including improved sleep, enhanced recovery, and increased vitality. Explore how personalized treatments can help you maintain the active lifestyle you love. Schedule your consultation today and take the first step toward lasting wellness. The post The Needle That Works: Why Acupuncture Isn’t Just for Stress Relief appeared first on Longevity Care Clinic.

Discover how your desk job might be affecting your posture, comfort, and energy levels over time. Learn about the common areas of tension from prolonged sitting and how these changes can impact your daily life and activities. Explore how Osteopathic Manipulative Treatment offers a gentle, holistic approach to addressing desk-related body changes. Find out how you can reclaim better posture and comfort to enhance your active lifestyle and overall wellness. The post Your Desk Job Might Be Reshaping Your Body: How to Reclaim Your Posture and Vitality appeared first on Longevity Care Clinic.

You Train Hard. But Do You Recover Smart? Every time you lace up for a workout, whether it's a brisk walk, a strength session, or a weekend game of tennis, your body works hard. Muscles contract, joints absorb impact, and your nervous system coordinates the entire symphony of movement. But here's the truth that experienced [...] The post Is Your Recovery Routine Missing the One Thing That Pro Athletes Swear By? appeared first on Longevity Care Clinic.

Forests play a crucial role in promoting health and wellbeing, but not all forests provide the same benefits. A large-scale study demonstrates how specific forest characteristics -- such as canopy density and tree species diversity -- can affect various health outcomes.

NIH researchers develop biomarker score for predicting diets high in ultra-processed foods  National Institutes of Health (NIH) (.gov)View Full Coverage on Google News

NIH researchers develop biomarker score for predicting diets high in ultra-processed foods  National Institutes of Health (NIH) (.gov)View Full Coverage on Google News

Multiple obstacles, including vascular connections and immune suppression, made the pioneering bladder transplant procedure a challenge.

Physical activity helps protect older adults against disease. A new study reveals that the health benefits also apply to those who exercise less than the recommended amount. The research is published in The Journal of nutrition, health and aging.

By: Chuck Schembre Historically, we have been greatly miseducated about plant nutrition by universities and fertilize sales companies. When it comes to understanding how and why balanced plant nutrition leads to optimizing disease and pest resistance, we can give big thanks to experts such as John Kempf and Dr. Kristine Jones, just to name a […] The post Regenerative Strategies for Orchard Disease and Pest Control Part Two: Implementing a Systemic Approach appeared first on Understanding Ag.

SQSTM1 is also known as P62. The protein expressed by this gene assists in the selection and transport of materials to be recycled via autophagy, an important stress response mechanism. Once a protein or structure has been decorated with a ubiquitin molecule, SQSTM1 binds to that protein or structure as a part of the complicated process of shuttling it to a lysosome where it can be broken down. Thus too little SQSTM1 impairs autophagy and more SQSTM1 can enable more efficient autophagy. This can influence the pace of aging, as illustrated by the numerous interventions that both slow aging and which feature enhanced autophagy. In at least a few such cases, such as for calorie restriction, autophagy has been shown to be necessary for slowed […]

A lack of recognition and the de-professionalization of nursing is driving many to leave the profession in significant numbers, according to the findings of a new study.

There is increasing interest in finding drugs, known as gerotherapeutics, that can slow aging and help people live longer. Metformin, a common diabetes drug, is being studied because it affects several aging-related processes.

People rely on animal products such as meat, fish, eggs and dairy for vitamin B12, or supplements and fortified foods.

In recent years, the “obesity paradox” has challenged long-standing assumptions about body weight and health outcomes, particularly in cardiovascular disease. While obesity is widely recognized as a significant risk factor for the development of cardiovascular complications, intriguingly, epidemiological data have demonstrated that obese patients sometimes experience lower mortality rates after cardiovascular events than their leaner […]

Microplastics could play a hidden role in the relationship between ultra-processed foods and certain neurological disorders, according to new research.

It's well-known that obesity is a risk factor for cardiovascular disease. But some research suggests that while people who are obese are more likely to develop cardiovascular problems, they're also less likely to die from them. This counterintuitive finding is called the "obesity paradox."

Physical activity helps protect older adults against disease. A new study reveals that the health benefits also apply to those who exercise less than the recommended amount.

Scientists have created engineered nanostructures that bind monomers and oligomers of harmful amyloid beta (Aβ) protein, preventing them from entering neurons and drastically increasing the cells’ survival in vitro [1]. Don’t let them […]

Arnold Schwarzenegger says hundreds of millions of people are suffering from arthritis and are too afraid to take a step they may need: body part replacement.

Arnold Schwarzenegger says hundreds of millions of people are suffering from arthritis and are too afraid to take a step they may need: body part replacement.

Rejuvenate Biomed to study how metformin-galantamine combo impacts physical function, muscle strength and fatigue resistance in COPD patients. The war … Continue reading "Metformin combination therapy enters Phase 2 sarcopenia trial" The post Metformin combination therapy enters Phase 2 sarcopenia trial appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

San Francisco’s Frontier Tower transforms urban vacancy into living lab for longevity science, clinical translation and communal acceleration. As the … Continue reading "Vertical villages and the architecture of aging" The post Vertical villages and the architecture of aging appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

Aging remains one of the most complex biological phenomena, governed by a mosaic of interdependent molecular and cellular processes. Among these, genomic instability and telomere attrition are universally recognized as central hallmarks that drive progressive physiological decline. Recent advances in microbiome research have uncovered a profound connection between the gut microbial ecosystem and the integrity […]

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Researchers identify a decline in NAD levels as a key driver of T cell dysfunction. Continue reading Aging reduces CAR-T cell effectiveness by impairing metabolism on Tech Explorist.

What would it take to create a cyborg brain like the one in the new TV show The answer reveals what makes our own brain so unique

And more health news stories you need to read today.

A hidden link between impulsivity and obesity may not be fixed in human biology but shaped by the cities we live in. Using a novel engineering-based approach, researchers found that attention-deficit/hyperactivity disorder (ADHD) contributes to obesity not only directly through known biological pathways but also indirectly, by reducing physical activity.

To better understand the potential therapeutic benefits of heritage art practices, researchers examined the impact of these practices on mental and physical health.

Danish drugmaker Novo Nordisk is teaming up with California-based biotech Septerna to develop new pills to treat obesity, type 2 diabetes and other metabolic diseases.

A sizable portion of the health benefits (and life extension in short-lived species) resulting from the practice of calorie restriction is triggered by sensing of levels of specific amino acids. Methionine is one of the more important such amino acids, and researchers have demonstrated that low-methionine diets can produce some fraction of the benefits of calorie restriction without reducing calorie intake, at least in rodents. Just as there are calorie restriction mimetics, molecules that trigger some of the same biochemical responses to calorie restriction, there should in principle be methionine restriction mimetics. Researchers here discuss one such methionine restriction mimetic, though note that nowadays everything in this part of the field is filtered through the lens of treating obesity, regardless of possible benefits to people […]

The standards represent the American Diabetes Association’s effort to address the stigma that affects healthcare access, quality, and outcomes for people living with obesity.

Chronic inflammation is a major component of aging, disruptive to tissue structure and function. Researchers here review some of what is known of the immune system dysfunction associated with cerebral small vessel disease, noting various measures reflective of inflammation. A number of lines of evidence point to inflammation of the vascular endothelium, the inner lining of blood vessels, as important in the development of vascular conditions such as atherosclerosis and small vessel disease. One should expect sustained inflammation to be disruptive to all of the structures and functions of vascular tissue, however, including the all-important blood-brain barrier that lines blood vessels in the brain. Cerebral small vessel disease (cSVD) refers to all pathologies of the brain's arterioles, capillaries, and venules. cSVD is highly prevalent with […]

“Nutrition does play a role in keeping our lungs healthy.” Here’s what primary care doctors need to know.

As the global population ages, the challenge of effectively treating cancer in older adults becomes increasingly urgent. Immunotherapy, particularly CAR-T cell therapy, represents one of the most promising frontiers in cancer treatment, leveraging the body’s own immune system to identify and eradicate malignant cells. However, a groundbreaking study published recently in Nature Cancer by scientists […]

As people age, their immune systems become less efficient, posing a challenge for cancer therapies that rely on harnessing immune cells.

6 Popular Foods And Beverages That GI Doctors Purposely Limit In Their Own Diets  BuzzFeed

6 Popular Foods And Beverages That GI Doctors Purposely Limit In Their Own Diets  BuzzFeed

This Better-For-You Banana Chocolate Bread is part of a series of recipes exclusively developed for NOVOS, aligning with the NOVOS Longevity Diet principles. Unlike conventional banana breads that are loaded […] The post Better-For-You Banana Chocolate Bread first appeared on NOVOS.

This Balsamic Chicken and Apple Harvest Salad is part of a series of recipes exclusively developed for NOVOS, following the principles of the NOVOS Longevity Diet. While many recipes focus […] The post Balsamic Chicken and Apple Harvest Salad first appeared on NOVOS.

In an illuminating advance for psoriasis research, new findings published in the Journal of Investigative Dermatology reveal that residual inflammation persists in a substantial subset of psoriasis patients undergoing biologic therapy—even when skin symptoms are markedly improved. This lingering inflammation extends beyond the skin and is closely associated with obesity, fatty liver disease, and systemic […]

New research shows that in patients with psoriasis, even though their skin responds well to treatment with biologics, inflammation can linger, leading to broader health implications such as obesity and cardiovascular and fatty liver disease.

Food cravings are the downfall of many dieters, who feel locked in an eternal battle with their willpower to resist the tempting sweets, snacks and other foods they love.

A new study led by researchers at Tulane University suggests that people with high blood pressure can significantly reduce - and possibly eliminate - their increased risk of premature death by controlling several key health risk factors at once.

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a new way to reduce obesity.

Obesity causes temporary disruptions, but not permanent structural changes, in the liver’s molecular network that regulates adaptation to starvation. Researchers led by Keigo Morita and Shinya Kuroda at the University of Tokyo have discovered that obesity causes a temporary disruption in how the liver adapts to starvation. Despite this functional disturbance, the underlying structure of [...]

A systematic review and meta-analysis evaluated the effects of dietary interventions on depression and anxiety in adults. The review found that calorie-restrictive and low-fat diets may reduce depression symptoms in those with high cardiometabolic risk, but the certainty of these findings is low.

New insights from longevity research suggest that lifestyle—not just genetics—plays a vital role in living a longer, healthier life. While rare individuals like 115-year-old Ethel Caterham may benefit from exceptional genes, research shows that physical activity, diet, sleep, and stress management are key factors that can significantly influence lifespan.

New paper proposes tackling aging organ by organ, cell by cell, using proactive, systemic therapies based on replacement rather than … Continue reading "Modular replacement could reframe how aging is addressed" The post Modular replacement could reframe how aging is addressed appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

The testes manufacture testosterone, generally important to long-term health. Further, germ cells resident in the testes manufacture sperm. This process of spermatogenesis is necessary for reproduction. Both of these functions decline with age. As is the case for near all outcomes of degenerative aging, the research community has yet to construct a clear model of cause and effect that reaches from the known root causes of aging to declining function in the tests. Cellular biochemistry is complex and incompletely mapped, and aging is a further complexity imposed upon those systems, not just as the level of individual cells, but also at the level of tissues containing enormous numbers of interacting cells of different types. It is a challenging task. Researchers regularly uncover intermediary mechanisms in […]

A groundbreaking initiative at the Keck School of Medicine of the University of Southern California (USC) is set to redefine the frontiers of aging research and therapeutic intervention. Fueled by a transformative $10 million endowment from philanthropists and legal luminaries R. Rex Parris and his wife Carrol Parris, the newly established USC Parris Longevity Accelerator […]

The results of a Phase 1 trial of the well-known senolytic combination of dasatinib and quercetin (D+Q) in patients with Alzheimer’s disease have […]

MONDAY, May 19, 2025 — Doctors in Southern California have performed the first human bladder transplant, offering new hope to people with serious bladder problems.The surgery was done earlier this month by two doctors from the University of C...

A hidden link between impulsivity and obesity may not be inherently rooted in human biology, but rather, shaped significantly by the environment of the cities we inhabit. This groundbreaking assertion has emerged from a novel research initiative led by scholars from NYU Tandon School of Engineering and Italy’s Istituto Superiore di Sanità. The findings illuminate […]

In sport, the margin between success and failure is often measured in milliseconds. It could be a cricketer adjusting their foot positioning, a runner refining their sprint start or a footballer perfecting their passing.

Forests play a crucial role in promoting health and well-being, but not all forests provide the same benefits. A large-scale international study, co-led by the University of Surrey and the University of Ghent, demonstrates how specific forest characteristics—such as canopy density and tree species diversity—can affect various health outcomes.

Growing emphasis on self-reliance and trade barriers could impair the ability of people to consume healthy and sustainable diets around the world. Research teams from the University of Göttingen and the University of Edinburgh investigated the extent to which 186 countries can feed their own populations solely through domestic production. The study was published in the journal Nature Food.

Click here to read the Cover Story, "‘The time for change is now’: Lancet report may reshape how medicine views, treats obesity."I commend The Lancet Diabetes & Endocrinology commission for having an international team of experts across multiple disciplines come together toward a consensus definition of obesity. The initiative was partly funneled by pervasive bias and stigma in the medical and lay community. The aims targeted access, equity and coverage issues that most patients are facing not only in the U.S., but across the globe.The commission highlights the limitations of

New recommendations from an international commission could dramatically change the way obesity is diagnosed, treated and discussed worldwide.In January, an international group of 58 experts in obesity published a report in The Lancet Diabetes & Endocrinology that reframes the criteria for diagnosing and defining obesity. Francesco Rubino, MD, chair of the Lancet Diabetes & Endocrinology Commission and professor of metabolic and bariatric surgery at King’s College London, said the group was formed to conduct a thorough review of the current scientific evidence on obesity and

A major new meta-analysis from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has found that glucagon-like peptide 1 receptor agonists (GLP1-RAs)—a class of medications used to treat obesity and diabetes—may also offer benefits for emotional well-being in overweight users.

MONDAY, May 19, 2025 — Couch potatoes are more likely to develop Alzheimer’s disease, even if they set aside time to work out each day, a new study says.People who spent more time sitting around were more likely to experience cognitive decline and b...

How an over-50s gym run by Age UK West Sussex, Brighton and Hove is helping older people get moving.

Obesity medications in development could improve accessibility and affordability, according to a presenter at Obesity Medicine 2025.The use of GLP-1 receptor agonists and other weight-loss medications have soared in recent years, especially in adolescents, young adults and those without diabetes. As a result, providers need to become more knowledgeable about these drugs as well as new ones that are making their way down the pipe.Healio spoke with Obesity Medicine Association President Harold E. Bays, MD, FOMA, FTOS, FACC, FASPC, FNLA, to learn more about what drugs look especially promising,

When we think about the future of food, it's unlikely that crickets, mealworms or grasshoppers come to mind. But believe it or not, insects might just be one of the most promising answers to two big global problems: feeding a growing (and aging) population and fighting climate change. As the world's population heads towards 10 billion by 2050, we're going to need a lot more food—and especially more protein.

Natural endocrine therapy is designed to help restore key protein signaling in diseased muscle to ‘more youthful, healthy levels.’ Longevity … Continue reading "Juvena kicks off first human trial of muscle regeneration therapy" The post Juvena kicks off first human trial of muscle regeneration therapy appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

The explosion in popularity of weight loss drugs such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) has brought a twist to the management of obesity. Patients usually need to exceed a minimum BMI threshold and have at least one weight related health condition to get a prescription for a weight loss drug. And that’s again put a spotlight on the way obesity is defined, measured, and diagnosed. In January 2025, the Lancet Diabetes and Endocrinology global commission on clinical obesity tackled this head on. The report recommended a new framework that moves away from BMI as a singular indicator and instead approaches obesity as a disease spectrum.1 Experts say that not knowing what BMI means can lead to incorrect assumptions about a person’s health and risk of disease. This can affect the quality of care patients receive as well as hinder efforts to prevent and treat obesity.2Simple, but flawed...

The tumor suppressor protein p53, encoded by the gene TP53, is thought to be a component of the trade-off between tissue maintenance and cancer risk that contributes to species life span. Too much p53 activity and cancer risk declines but life span shortens as tissue maintenance is also suppressed. To little p53 activity and life span increases, but so does cancer risk - eventually to the point of cutting short that extended life. Evolution comes to some balance for any given niche, but perhaps there is something to be learned from other species that could inform possible approaches to the control of cancer in our own species. Several molecular mechanisms have been purported to regulate aging and influence lifespan - many of which have been […]

It is well established that hearing loss and cognitive decline correlate with one another. There is some debate over causation, the degree to which hearing loss might contribute to cognitive decline versus both outcomes arising from the same underlying mechanisms of cell and tissue damage that drive aging. Recent studies strongly suggest that loss of hearing does accelerate cognitive decline, but this doesn't rule out shared contributions to both conditions from underlying processes or a bidirectional relationship of mutual causation. Hearing loss (HL) of moderate or higher grades is common in older adults with increasing prevalence as people age, rising from 12% at the age of 60 years to over 58% at 90 years. HL in midlife is one of the main potentially modifiable risk […]

A meta-analysis of 14 studies shows that adherence to the DASH diet helps reduce the risk for colorectal cancer.