Life Extension Technologies

Hormone replacement therapy is a popular treatment for women leading up to or following menopause. Manipulating sex hormones is a very blunt strategy, with potentially significant downsides, and a high variation in outcomes between patients, but the medical community has accumulated a great deal of experience in delivering this class of therapy. In the matter of assessing how this sort of approach affects aging, the research community is presently engaged in a process of gathering as much data as possible on how aging clocks interact with various therapies thought to influence aging or age-related disease. The accuracy of the clocks in the environment of any given therapy is unknown, and the effect of the therapy on the clock is unknown, and so the way forward […]

It is by now well established that senescent cells promote senescence in neighboring cells. This is a useful and necessary part of the benefits of the transient presence of senescent cells in the contexts of cancer suppression and coordination of wound healing. But when senescent cell clearance falters in later life, and senescent cells begin to linger and accumulate, this promotion of further senescence makes matters worse. One of the ways in which senescent cells promote senescence is via relatively well mapped and well understood inflammatory signaling. Here, however, researchers note that there are other pathways involved, in which the signaling involves the contents of small extracellular vesicles. Interfering in senescent cell signaling as a basis for therapy is likely a more challenging path forward […]

A stable-pool strategy can move cell line development off the critical path to Phase I while preserving a path to a conventional clonal cell line as a program matures. The post Rethinking the Clone-First Paradigm for First-in-Human Biologics appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers found that the gene preserves bone stem cell supply throughout life, and say the discovery advances understanding of stem cell biology and could indicate potential therapeutic approaches to improve bone healing and regeneration in aging and disease. The post Gene That Preserves Bone Stem Cell Supply Throughout Life Identified appeared first on GEN - Genetic Engineering and Biotechnology News.

In a Viewpoint, researchers examined evidence that exercise can reduce symptoms of depression and anxiety, support cognition, and may help lower the risk of cognitive decline, although evidence for dementia prevention remains largely observational. The authors argue that exercise should be prescribed as a structured component of brain-health care, with individualized recommendations that account for medical conditions, safety, and barriers to participation.

A phase 1 trial found that a pill of 16 selected beneficial bacteria was safe for stem cell transplant patients and was associated with fewer bloodstream infections.

We all want a well-functioning immune system to help us fight invasive bacteria and viruses and recover faster from illness. Popular "immune-boosting" ideas, however, might be more of a hindrance than a help.

The action of a key gene is required to maintain a lifelong supply of stem cells that make bone healing possible, a new study finds.

Tuesday, November 17, 2026 In an effort to reach an elusive continuity of the self, some far-thinking technologists are working on ways to keep your brain going—even beyond death. Join science editor Mary Beth Griggs and senior editor for biomedicine Antonio Regalado for a conversation exploring possible paths to keep your mind going, including gradual…

A multi-omics study shows that lactate produced by senescent breast cancer cells drives the SASP through histone H3 lactylation at inflammatory gene loci.

A study of rooftop-harvested rainwater in Rivers State, Nigeria, found that metals from atmospheric deposition, crustal dust, and roofing materials posed low non-carcinogenic health risks.

Alcohol is deeply embedded in British culture, from celebrations and religious ceremonies to everyday social life. Government guidelines offer a way to reduce the risks associated with drinking, but consuming alcohol within recommended limits does not mean those risks disappear.

A GIS and AI-assisted planning framework tested on aging districts in Sharjah and Ajman proposes walkable street networks, land-bank reuse, parking consolidation and pocket greens without greenfield expansion.

Chick satellite cells from breast and leg muscles show opposite patterns of proliferation and differentiation when cultured under identical conditions, a new study finds.

A new mini-review proposes that durable senescence-like states in dorsal root ganglion sensory neurons may help explain why pain persists after injury, while stressing the evidence remains a testable hypothesis rather than a proven cause.

The state of the gut microbiome is at least as influential on long term health as lifestyle choices like exercise. The composition of the gut microbiome changes with age for reasons yet to be fully explored. Inflammatory populations grow at the expense of populations producing metabolites necessary for tissue function. Connections can be drawn between near every organ and system in the body and specific metabolites or specific microbial populations influencing them. In turn the immune system and other organs influence the gut microbiome. Fortunately, it is possible to produce the lasting restoration of a more youthful gut microbiome via strategies such as flagellin immunization and fecal microbiota transplantation. Unfortunately, probiotic and related strategies are as yet incapable of producing such sizable and lasting changes, […]

A new mouse study shows the approved cystic fibrosis drug ivacaftor reduced pulmonary fibrosis by suppressing senescence in alveolar type 2 cells through CFTR-PTEN signaling.

Women with HIV who achieve sustained virologic suppression live longer than demographically similar men, a difference resembling the female longevity edge in the general population.

A new review examines how plant-derived compounds such as polyphenols, flavonoids, alkaloids and isothiocyanates may target the breast cancer stem cells linked to recurrence, metastasis and treatment resistance.

Scientists have uncovered unexpected changes in brain chemistry following prolonged, intense exercise in mice. Two days after an exercise test, mice subjected to weeks of grueling training still had elevated dopamine levels in the hippocampus, a brain region involved in memory and emotional regulation. The findings suggest that excessive exercise without adequate recovery can produce [...]

A multicomponent nutritional supplement has been found to improve markers of vascular health in a randomized controlled trial led by the University of Surrey. The formulation combined ingredients (vitamins, minerals, amino acids and plant-derived bioactives) selected for their relevance to several biological processes associated with aging.

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, and collaborators have pioneered a new approach to preventing dangerous bloodstream infections in patients receiving donor stem cell transplants for blood cancers.

A study led by researchers from the Germans Trias i Pujol Research Institute (IGTP) and the Blood and Tissue Bank (BST) has developed and validated a manufacturing platform for extracellular vesicles that meets pharmaceutical quality requirements, marking a key step toward their clinical application.

Cells contain hundreds of mitochondria, constantly fusing together, replicating by splitting apart, and swapping component parts. Mitochondrial function is vital to cell health, and declining mitochondrial function is an important component of degenerative aging. Some of the answers as to why mitochondrial function declines with age are likely buried somewhere in the complex interactions of mitochondrial structure, the dynamics of mitochondrial fusion and fission, and the operation of the mitochondrial quality control processes of mitophagy. Mitophagy is both necessary to maintain function by destroying worn mitochondria, but it also seems quite sensitive to changes in structure and size of mitochondria, as happens when the dynamics of fusion and fission change. In today's open access paper, researchers demonstrate that compounds that improve the activity of mitofusin, […]

Researchers have identified a mechanism involving fatty acid metabolism that may determine whether a damaged cell enters senescence and persists in the body or is eliminated through cell death. Published in the journal Cell, the study could open new avenues for treating age-related diseases. Researchers from the University of Eastern Finland contributed to the international study.

A surprising discovery suggests that rejuvenating the liver could help protect against Alzheimer’s disease and heart disease. USC researchers found that an experimental drug restored aging liver cells in rats, cutting levels of an Alzheimer’s-linked protein in half and bringing bad cholesterol down to youthful levels. The treatment also revived a previously unknown communication system that helps liver cells remove harmful substances from the bloodstream.

A protein that helps build teeth may one day be used to allow damaged teeth to repair themselves.

Researchers at UC Santa Barbara, UC San Francisco and international collaborators are uncovering the cascade of molecular events that happen when women undergo menopause, a time of life marked by endocrine changes and symptoms like hot flashes, brain fog and sleep disturbances.

In a landmark achievement in the field of genetic medicine, researchers have reported the very first published case in a peer-reviewed journal of a successful clinical treatment of a patient with alpha-1 antitrypsin deficiency (PiZZ) using in vivo gene therapy.

A cross-sectional study of 615 adults in the Loma Linda Blue Zone area and surrounding communities found that vegetarian diets were more common among older adults and Seventh-day Adventists, with vegetarians also reporting significantly lower BMI than non-vegetarians. The findings raise concerns about whether younger generations are maintaining the region's traditional dietary practices, although further research is needed to establish whether vegetarian adherence is declining over time.

Researchers at the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have discovered a group of particularly long-lived blood stem cells in mice. These cells remain in a dormant state for an exceptionally long time while retaining their ability to generate new blood cells. This newly discovered cell population may be responsible for sustaining blood regeneration and immune defense throughout a mouse's entire life.

Some say they were introduced to the drug through wellness podcasts, free samples at gyms or fitness influencers.

In a cross-sectional analysis of 7,256 adults from the Maastricht Study, researchers found that greater adherence to the DASH and Dutch Healthy Diet patterns was associated with higher very-low-frequency (VLF) heart rate variability power, particularly among participants not taking beta-blockers. No significant associations were observed across time-domain HRV measures after full adjustment, and the findings do not establish that these diets improve cardiovascular function.

As the weather cools down, the race for functional interventions heats up. Last month, members of our field have been […]

Cells become senescent constantly throughout life, usually upon reaching the Hayflick limit to replication, but also in response to injury, high levels of cell stress, or potentially cancerous damage. Senescent cells cease to replicate, grow in size, and secrete pro-inflammatory signals to attract the attention of the immune system. In youth, the immune system clears senescent cells rapidly, but this becomes less efficient with advancing age for a range of reasons yet to be fully explored. Senescent cells appear to alter their biochemistry in ways that inhibit immune clearance, but the immune system as a whole also becomes less effective at all of its tasks. Senescent cells linger, accumulate, and disrupt tissue structure and function with their inflammatory signaling. The vascular system is vital to […]

John Hancock and MIT AgeLab’s second index finds no change since 2025, with care the weakest area and community the strongest. A middling grade, two years in a row. Americans scored 60 out of 100 on preparedness for longer lives in the 2026 Longevity Preparedness Index (LPI), released 27 October by John Hancock and the […] The post Americans score 60 out of 100 on longevity prep appeared first on Longevity.Technology.

In a surprising discovery, scientists found that certain diets associated with obesity can make cancer immunotherapy more effective in mice, challenging traditional assumptions about diet and cancer treatment. The findings suggest that the secret may lie in how food interacts with gut bacteria to strengthen the immune system's response to cancer.

Gastroenterologists weigh in on whether coffee on an empty stomach truly spikes cortisol levels or causes acid reflux and other GI symptoms.

Some say they were introduced to the drug through wellness podcasts, free samples at gyms or fitness influencers.

What does it mean to feel that a part of us will live on after we are gone? A new study of nearly 3,000 adults found that people who believed they would be remembered by others tended to report better mental health, a stronger sense of meaning and lower levels of problematic substance use and addictive behaviors. The findings point to a possible link between our sense of lasting significance and the way we cope with stress, uncertainty and mortality.

Guy Penrod seeks prayers after disclosing a serious blood and bone marrow illness, telling Mark Lowry a transplant is the only potential fix.

Studies conducted in various countries indicate that approximately 60% of people over age 65 currently live with two or more chronic conditions. With the aim of reversing this trend and promoting healthy aging, European researchers have created a new personalized indicator that provides a detailed snapshot of a patient's metabolism by analyzing, with high precision, the chemicals the body produces to function.

Excessive physical exercise affects more than just the muscles; it can also alter brain chemistry. A new study published in the journal Neuroscience revealed that exhaustive training without adequate rest alters the regulation of dopamine in the hippocampus, a brain region closely linked to memory and the regulation of emotions.

A patient has undergone pioneering stem-cell therapy to treat Parkinson's disease, the Japanese drugmaker behind the treatment said on Friday, in a world first following its conditional approval in the country.

Cells are very particular about the proper locations of their contents. For example, DNA is packaged in the nucleus in a highly specific way, but researchers are still trying to understand how this happens. For stem cells in the brain of a larval fruit fly—a model organism used to study processes such as early development—the DNA is organized so that the center of each strand, called the centromere, is at the top of the nucleus.

In a new study, late-life treatment with a three-element senolytic vaccine led to lower senescence markers and a 12% increase […]

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Decades founder Eva Novak on why the blue zone idea can survive scrutiny, but only if validation becomes independent, open and repeated. In early October, a mountain village in central Sardinia was put forward as the world’s newest blue zone. Of Bolotana’s roughly 2,300 residents, 19 turned 100 between 2021 and 2025, and at that […] The post Every blue zone should come with an expiry date appeared first on Longevity.Technology.

Healthy eating may help cancer survivors live longer and lower their risk for ischemic heart disease, heart failure or stroke, according to data published in JACC: Advances.Implementing or maintaining a high-quality, heart-healthy diet such as the Mediterranean, Dietary Approaches to Stop Hypertension (DASH) or Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet after a cancer diagnosis may have cardioprotective benefit and enhance overall survival, researchers reported.In addition, the reduced risk for CV events was not observed with high intake of a healthy

Researchers here propose that greater efforts should be devoted to considering the variety of G-protein coupled receptors (GPCRs) as a regulatory network in the matter of aging and age-related disease. Aging produces sweeping changes in protein levels, gene expression, protein function and interactions, and one can thus make similar arguments for many different classes of molecule found in cells. The question is always whether one can justify intervention in a given mechanism on the basis of its importance to aging: where does it sit in the interacting network of cause and consequence? Is it causing a great deal of downstream harm, or is it more of an end stage consequence? How close is it to root causes of aging? This is a lot harder to […]

Frontiers in Medicine has retracted a 2020 mouse study on exosomal miR-25 and fracture healing after image integrity concerns and missing raw data.

A new study shows that the RNA-binding protein MSI1 stabilizes the ferritin-like transcript Fthl17c, preserving the ferrous iron supply that TET enzymes need to keep DNA hypomethylated and mouse embryonic stem cells pluripotent.

Researchers developed an in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes, which showed normal karyotype, intact p53, and responses to thirteen reference substances consistent with published genotoxicity reports.

A study of 120 healthy older adults found that general cognitive functions mediate age-related reading decline, while visuo-spatial attention moderates it.

A new review in Cell Regeneration explains why transient senescent cells support muscle repair while persistent senescence in aged or dystrophic muscle undermines it.

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding important evidence on sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

A new study proposes the contextual palimpsest, a temporally layered design framework in which past traces and present interventions coexist in regenerated cultural buildings.

New work shows that loss of the chromatin-binding protein Prospero leaves fly CNS cells of mixed identity that fail to divide or divide once extra, without dedifferentiating into stem cells.

Studies conducted in various countries indicate that approximately 60% of people over the age of 65 currently live with two or more chronic conditions simultaneously.

An international study reports 60% progression-free survival at 10 years after autologous bone marrow transplantation, adding evidence of sustained positive clinical outcomes and long-term safety in patients treated for early severe systemic sclerosis.

In rat bone marrow stem cells, the TLR4 inhibitor TAK-242 suppressed LPS-induced inflammatory gene expression while leaving osteogenic differentiation largely unimpaired by day 14.

A new review argues that stem cell grafts can protect tissue and communicate with host circuits in selected spinal cord injury models, but no study has yet linked product molecular features to recovery in one experiment.

A new review summarizes how basal stem cells sustain lifelong olfactory epithelium renewal and how single-cell and organoid technologies are reshaping the field.

Cancer survivors face elevated cardiovascular risk, but a heart-healthy diet may help mitigate it, a UK Biobank study suggests.

This eBook brings together perspectives from across the AAV development and manufacturing continuum. It explores how early commercial planning can help avoid costly delays, how standardized platform approaches and off-the-shelf plasmids can streamline development, and how next-generation innovations are helping overcome long-standing manufacturing bottlenecks. The post Building the Future of AAV Gene Therapy appeared first on GEN - Genetic Engineering and Biotechnology News.

A prospective cohort study of 364 street-involved youth in Makassar, Indonesia, found that baseline drug use and high social vulnerability each raised the risk of adverse health outcomes, with the combination producing the greatest risk.

Stem cell therapies involve a stage of expansion of cells in culture prior to injecting them into the patient. The research community has realized that both the state of the original source cells and small variations in the subsequent cell culture environment can result in large differences in the quality of the transplanted cells. For example, how many of the cells in the culture have become senescent, and are thus now generating pro-inflammatory signals. There are other possible variations in cell state that could contribute negatively to outcomes, diminishing any benefits resulting from the therapy, however. Differences in cell state and behavior may be the cause of much of the well-known and undesirable variability of outcomes in stem cell therapy. Some clinics may have started […]

A meta-analysis of 29 randomised trials finds exercise rehabilitation around valve procedures may improve walking distance, fitness, and recovery, though evidence certainty is very low for most outcomes.

A new review evaluates preclinical evidence that adipose-derived stem cell extracellular vesicles could multitarget the pathological processes driving diabetic microangiopathy.

A mouse study finds that age- and diet-dependent changes in astrocyte complexity within the hippocampal temporoammonic pathway parallel spatial learning performance.

A systematic review finds that only 47 human studies address fusion between mesenchymal stem/stromal cells and tissue-specific cells, suggesting regenerative potential in the cardiovascular, muscular, and nervous systems while noting that spontaneous fusion is rare.

A new narrative review details how hyperglycemia, Schwann cell dysfunction, and disrupted calcium and iron balance impair peripheral nerve regeneration after traumatic injury.

A study of nearly 13,000 adults found that people consuming the most artificial sweeteners experienced a 62% faster decline in memory and thinking skills, equivalent to approximately 1.6 additional years of brain aging. Six popular sweeteners were linked to faster cognitive decline, raising concerns about the long-term brain health effects of common sugar substitutes, although causation was not established.

A one-hour exposure to activated protein C keeps human blood stem cells quiescent and improves their short-term serial engraftment in mice, while thrombin acts on the same receptor to drive differentiation and impair transplantation outcomes.

A new review in Biological Research surveys cardiac stem and progenitor cell populations, finding that classic markers c-kit and Sca-1 mostly label endothelial cells without cardiomyogenic potential.

Research by The Business Research Company projects the longevity biotech market will exceed $31 billion in 2030, growing at an 8% compound annual growth rate. It is expected to constitute about 78% of the broader longevity and anti-senescence therapy market, near $40 billion, and represent roughly 0.3% of the healthcare services industry value in 2030. […] The post Longevity biotech market set to top $31b by 2030 appeared first on Longevity.Technology.

A graph neural network trained on more than 14,000 brain scans maps local cortical aging at millimeter resolution and links it to cognitive impairment in Alzheimer's disease.

In the Drosophila ovary, Notch activation upregulates the E2 enzyme Ubc10, which teams with the E3 ligases Ari-1 and Cul3 to degrade the Hedgehog effector Ci and specify cap cells that form the germline stem cell niche.

Peripheral nerves are capable of regeneration to restore connections across gaps caused by injury, but the larger the gap the less likelihood of a successful outcome. The medical community has developed approaches that help by laying guides along the path that regrowth must take, often composed of donor nerve tissue, which may be taken from elsewhere in the patient, but these are far from optimal. There is considerable research interest in the development of entirely artificial nerve regrowth guides that have a low cost and high rate of success in stimulating the necessary regeneration for a complete restoration of function. The paper here is an example of this sort of research and development, focused on bioprinting an implantable path for nerve regrowth. Conventional cell-laden electro-direct […]

A cell-culture study reports that prodigiosin reduced apoptosis and oxidative stress in BMSCs exposed to chemically induced hypoxia, with effects linked to HIF-1α/YAP-associated signaling.

Researchers report generating human chemically induced pluripotent stem cells from umbilical cord-derived mesenchymal stem cells using an optimized small-molecule protocol under normal oxygen conditions.

A 12-week randomized trial found that multi-strain probiotic supplementation did not improve arterial stiffness or central blood pressure beyond an energy-restricted diet in adults with hypertension and overweight or obesity.

A study of two Vojvodina farms finds regenerative management can match conventional yields, though short-term profits remain unstable.

An integrated blood and CSF multi-omics analysis of the SMART-MS randomized trial found that intrathecal mesenchymal stem cell therapy in progressive multiple sclerosis was associated mainly with compartmentalized CSF proteomic changes rather than broad systemic immune alterations.

A published correspondence argues that statistical artefacts, BMI adjustment effects and reverse causation may explain reported gut microbiota associations with sarcopenia in older Iranian adults.

A new review argues that mushrooms and the antioxidant L-ergothioneine show anti-aging effects in laboratory models, while human evidence remains largely observational.

How to train for lasting strength—and keep doing what you love as you age. The post A longevity playbook for building strength and muscle mass appeared first on Peter Attia MD.

A case report describes a 64-year-old woman with multiple myeloma and an SCN5A overlap channelopathy who underwent autologous stem cell transplantation without arrhythmic events under a structured risk mitigation strategy.

Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state in vitro, with the effect reversible on drug withdrawal.

Silencing β-catenin1 in the flatworm Macrostomum lignano blocks tail regeneration and blastema formation, but unlike in planarians it never induces head regeneration, revealing that the head-rescuing response is a planarian specialization rather than an ancestral flatworm trait.

A new review argues that neural stem cells may aid spinal cord injury recovery mainly by reprogramming macrophages and other immune cells rather than replacing lost neurons.

The FDA says Calibrate IV Hydration marketed unapproved stem cell and exosome products. The warning highlights regulatory concerns and questions consumers should ask before receiving an infusion.

A retrospective study of 29 severe systemic sclerosis patients found that autologous hematopoietic stem cell transplantation reduced epidermal thickness and lowered several serum markers of epithelial activation six months after treatment.

A physics-informed TS-Mixer neural network predicted measured PEM fuel cell stack power with an R-squared of 0.969 on a 497-hour ageing dataset.

A large German survey analysis found that the age of exposure to child maltreatment subtypes, particularly emotional abuse around puberty, was strongly associated with adult internalising and externalising mental disorders in sex-specific patterns.

A mouse study found that hematopoietic stem cells engrafted during active bone marrow regeneration showed superior long-term reconstitution compared with cells engrafted after myeloablative conditioning.

A new study maps about 1,100 sites where PRC2 rapidly re-establishes itself in mouse embryonic stem cells after reversible depletion of the core subunit Suz12.

A new review argues that the hip's cotyloid fossa fat pad is a promising but still uncharacterized source of therapeutic stem cells, using the knee's well-studied infrapatellar fat pad as its benchmark.