Life Extension Technologies

Researchers from QIMR Berghofer in collaborat ion with the Francis Crick Institute, have unlocked the secrets of how brain stem cells enter and exit a resting state called ‘quiescence’ - a process with roots stretching back to the dawn of life. Their findings may lead to new approaches in brain health and cancer therapy.

Modern dairy cows are milk-producing powerhouses—some yielding more than 50 kg a day. But all that productivity comes at a price: their mammary glands often suffer from inflammation and cellular stress, which not only reduces milk quality but also affects the cows' well-being.

A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how senescent cells behave in living tissues and influence aging through complex, heterogeneous mechanisms. The research is published in the journal Nature Aging.

In the wake of successful tuberculosis (TB) treatment, a perplexing clinical challenge emerges: a subset of patients experience relentless and progressive lung damage that severely impairs respiratory function. Despite globally concerted efforts to combat Mycobacterium tuberculosis infection, the scars it leaves behind have long been shrouded in mystery, hampering effective strategies to repair or reverse […]

author Eric Topol unpacks the rise of biological age tests—from organ clocks to immune system clocks—and how they might revolutionize early diagnosis of disease

“We can just see empirically that all the strength in the world, if it doesn't come with reasonable mobility, is going to be somewhat limiting at a minimum in quality of life.” —Peter Attia The post 356 – AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more appeared first on Peter Attia.

The age at which a woman has her first period can offer valuable clues about her long-term risk for conditions like obesity, diabetes, heart disease and reproductive health issues, according to a study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

Movement helps your mood, but it's not one-size-fits-all. Exercising for fun, with friends, or in enjoyable settings brings greater mental health benefits than simply moving for chores or obligations. Researchers emphasize that context — who you're with, why you're exercising, and even the weather — can make or break the mood-boosting effects.

Metabolic health factors, including small increases in blood sugar, are the main drivers of change in the reproductive systems and sexual functioning of aging men, according to a study being presented Saturday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

Further details about HoloMem’s holographic tape have come into view.

Isometric exercises like wall squats are gentle on your body, but can enhance your fitness in a surprisingly efficient way, discovers Grace Wade 

Pfizer Inc. (NYSE:PFE) is one of the 13 Best Large Cap Stocks to Buy Right Now. On July 10, Pfizer Inc. (NYSE:PFE) shared positive topline results from the overall survival (OS) analysis from the Phase 3 EMBARK study. This study looked at how XTANDI (enzalutamide), in combination with leuprolide and as a monotherapy, works for […]

Ever wonder why some people thrive on high-intensity workouts while others dread even gentle yoga? A new study reveals that your personality may hold the key. Researchers found that traits like extroversion and neuroticism predict not just which exercises people prefer, but also how likely they are to stick with them—and even how much stress [...]

Getting started or scaling up regenerative agriculture practices requires more than just passion – it needs resources.  The good news?...

The Bronx Zoo has reopened its World of Darkness exhibit after a 16-year hiatus.

The way, place, and reason you exercise may matter more than how much exercise you actually do. Exercise is frequently linked to improved mental health, but a new study from the University of Georgia suggests there’s more to the story than just physical movement. According to the researchers, the mental health benefits of exercise can [...]

New research shows adults aged 35 to 64 prescribed gabapentin for chronic pain are twice as likely to develop dementia and three times more likely to develop mild cognitive impairment.

A decade-long project measuring access to healthy foods worldwide is wrapping up in August, after shedding new light on the scope and specifics of nutrition insecurity, kickstarting solutions, and shifting the conversation around the affordability of healthy diets.

In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer's disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain.

A newly created cell model of the amniotic sac could reveal new insights into early pregnancy, as well as generate helpful products for medical use.

In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer's disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain.

Nerve cells are not just nerve cells. Depending on how finely we distinguish, there are several hundred to several thousand different types of nerve cell in the human brain according to the latest calculations.

Cleaning products, candles, cribs, and cosmetics are just a few of the common household items that emit formaldehyde, a colorless, odorless chemical that, when present in the air at levels higher than 0.1 parts per million, has been found to be a risk to human health.

Human epidemiological data exhibits a web of correlations between intelligence, education, wealth, lifestyle choices, social status, and longevity. Correlations are simple enough to discover, but determining causal relationships is much harder, particularly when pulling in the possible role of biological mechanisms. Nonetheless, there is an intriguing thread of research suggesting that there is some biological contribution to the correlation between intelligence and longevity. It may be that some aspects of the natural variation between individuals in physical robustness, or in resilience to age-related cell and tissue damage, can contribute to both intelligence and longevity. As today's open access paper makes clear, the measurement of intelligence is a tricky business. One can argue about the merits of the various approaches taken in humans, but an entirely […]

Ahead of the International Longevity Summit, José Cordeiro highlights Madrid’s rise as Europe’s new capital of healthy aging. Following its … Continue reading "Madrid takes the lead in Europe’s longevity race" The post Madrid takes the lead in Europe’s longevity race appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

ScienceMachine lands early stage funding for bioinformatician agent that can turn ‘raw data into breakthroughs in hours, instead of months.’ … Continue reading "Can this autonomous AI platform accelerate longevity drug development?" The post Can this autonomous AI platform accelerate longevity drug development? appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

The California Institute for Regenerative Medicine and its partners are selling thousands of stem cell samples before many of them are discarded.

Most people assume aging is something that just happens to you. But your daily habits, especially the food you put on your plate, have far more control than you've been told. What if one of the simplest changes you make today could drastically shift how you age decades from now? Carbohydrates are one of the most misunderstood nutrients in modern health culture. You've probably heard they're something to fear, cut out, or "earn" through exercise. But the truth is more nuanced — and far more powerful. Certain carbs are necessary for sustaining cellular energy, supporting brain health and protecting against the slow erosion of physical function that many people accept as inevitable with age. The real issue isn't whether you eat carbs; it's which ones. There's a world of difference between carbs that nourish your cells and carbs that accelerate inflammation and decline. And the earlier you understand that difference, the more time you have to put it to work. If your goal is to

A Chinese man has attracted widespread attention online after he bought a coffin for his 70-something mother to sit in and hired 16 men to carry it from the shop to his home as a gesture of filial piety. The unidentified man from Shuangxikou Town, Taoyuan County, Changde, in Hunan province, southern China, hired porters to carry his elderly mother home in a casket in the hope that doing so would bring her good fortune and longevity. A viral video shows the elderly woman sitting cheerfully inside...

Plasma proteomics reveals that the biological ages of key organs, especially the brain and immune system, strongly predict the risk of future disease and early death. These organ-specific “clocks” provide a new tool for identifying those at highest risk and personalizing preventive care.

Researchers have mapped human fat tissue at single-cell resolution, uncovering how obesity alters cellular stress, inflammation, and tissue structure. Weight loss reverses much of this damage, especially senescence in fat and vascular cells, but leaves some immune dysfunction behind.

The skin has two types of adult stem cells: epidermal and hair follicle. Their jobs seem well-defined: maintaining the skin, or maintaining hair growth. But as research from Rockefeller University has shown, hair follicle stem cells (HFSCs) can switch teams, pitching in to heal the skin when it receives an injury. How do these cells know it's time to pivot?

Chronic joint pain affects nearly 25% of adults in the United States. Over time, joints can deteriorate due to aging, injuries, or even a lack of movement. Fortunately, stem cell therapy offers a promising solution. By harnessing your body’s own cells, this treatment can help restore and rejuvenate your joints, making them stronger and more [...] The post Stem Cell Therapy: Strengthen Your Joints Naturally—No Surgery Needed appeared first on Longevity Care Clinic.

Research into reprogramming aims to induce some aspects of the dramatic change in gene expression and cell function that take place during early embryonic development, when adult germline cells shed the epigenetic changes characteristic of age to become young embryonic stem cells. Cell function becomes youthful, mitochondrial function is restored. Researchers can recapture the entire process, which is what happens when somatic cells are reprogrammed into induced pluripotent stem cells via exposure to the Yamanaka factors, but present efforts are turning to finding effective ways to induce only rejuvenation of function, without inducing pluripotency and loss of cell type. Exploration of what has come to be called partial reprogramming, rejuvenation without pluripotency or other undesirable cell state changes, started with the use of genetic technologies […]

Metabolic-associated steatohepatitis (MASH) is an advanced and progressive liver disease that potentially causes cirrhosis and hepatocellular carcinoma.

‘I’m a healthier person for playing a serial killer’: Michael C Hall on Dexter’s wildly improbable return  The Guardian‘Tight, sick, suspenseful’ — critics say ‘Dexter: Resurrection’ brings wicked humor and killer thrills, despite flaws  YahooDexter: Resurrection Episodes 1-4 Review  IGN‘Dexter: Resurrection’ Review: Against All Odds, Michael C. Hall’s Serial Killer Finds New Life  IndieWireEmpire State Building Turns Blood-Red for Highly-Anticipated Return of Iconic TV Villain  parade.com

‘I’m a healthier person for playing a serial killer’: Michael C Hall on Dexter’s wildly improbable return  The Guardian‘Tight, sick, suspenseful’ — critics say ‘Dexter: Resurrection’ brings wicked humor and killer thrills, despite flaws  YahooDexter: Resurrection Episodes 1-4 Review  IGN‘Dexter: Resurrection’ Review: Against All Odds, Michael C. Hall’s Serial Killer Finds New Life  IndieWireEmpire State Building Turns Blood-Red for Highly-Anticipated Return of Iconic TV Villain  parade.com

In this Lifespan interview, we speak with Gabriel Cian, founder of the 2060 Longevity Forum, about how his background in software shaped his views on healthspan innovation, the forum’s approach to scientific and investment credibility, and what he sees as […]

Adolescence is a crucial stage of human development. During this unstable period, teenagers experience numerous physical, emotional and social changes that can be extremely challenging. It is a time of identity construction, increased exposure to external pressures, and a search for autonomy. Without the right support, this can all take a significant emotional toll.

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A new process could help to treat liver disease without needing an organ transplant, a new study reveals.

Controversial system requires local NHS investment to maximize productivity The benefits of the UK health sector's Palantir-powered data and analytics system are being suppressed by the limits of writing back to NHS software, MPs heard this week.…

Colon cancer is spiking in young adults. Scientists are blaming the American diet  YahooGastroenterologist shares top warning signs of colon cancer, warns young people to watch out: 'No 1 is retinal bleeding'  Hindustan TimesWhat's behind the enormous increase in early-onset gastrointestinal cancers?  Medical XpressColon cancer sees alarming rise in young adults; Scientists blame this popular food habit  Times of IndiaDana-Farber Report Shows Alarming Rise in Many Gastrointestinal Cancers in Young People | Newswise  Newswise

Colon cancer is spiking in young adults. Scientists are blaming the American diet  YahooGastroenterologist shares top warning signs of colon cancer, warns young people to watch out: 'No 1 is retinal bleeding'  Hindustan TimesWhat's behind the enormous increase in early-onset gastrointestinal cancers?  Medical XpressColon cancer sees alarming rise in young adults; Scientists blame this popular food habit  Times of IndiaDana-Farber Report Shows Alarming Rise in Many Gastrointestinal Cancers in Young People | Newswise  Newswise

The candles on your birthday cake don't tell the whole story. As anyone who ever attended a high-school reunion can tell you, some people age faster than others.

As revenues from the anti-aging market-- riddled with hope and thousands of supplements–– surged past $500 million last year, Emory University researchers identified a compound that actively delays aging in cells and organisms.

It’s widely accepted that exercise can help people living with cancer, but new Edith Cowan University (ECU) research shows many oncology healthcare providers aren’t regularly including it in their treatment plans.

Psilocybin, the active compound derived from psychedelic mushrooms, significantly delayed cellular aging and extended lifespan in a preclinical study. Researchers observed a 50% increase in the lifespan of human skin and lung cells and a 30% increase in survival in aged mice treated with psilocybin.

What can lemurs tell us about inflammation and aging, aka "inflammaging" in humans? That's the question Elaine Guevara, a biological anthropologist who studies the evolution of life history and aging in primates, set out to understand.

Colon cancer is spiking in young adults. Scientists are blaming the American diet  YahooWhat's behind the enormous increase in early-onset gastrointestinal cancers?  Medical XpressGastroenterologist shares top warning signs of colon cancer, warns young people to watch out: 'No 1 is retinal bleeding'  Hindustan TimesColon cancer sees alarming rise in young adults; Scientists blame this popular food habit  The Times of IndiaDana-Farber Report Shows Alarming Rise in Many Gastrointestinal Cancers in Young People | Newswise  Newswise

Colon cancer is spiking in young adults. Scientists are blaming the American diet  YahooWhat's behind the enormous increase in early-onset gastrointestinal cancers?  Medical XpressGastroenterologist shares top warning signs of colon cancer, warns young people to watch out: 'No 1 is retinal bleeding'  Hindustan TimesColon cancer sees alarming rise in young adults; Scientists blame this popular food habit  The Times of IndiaDana-Farber Report Shows Alarming Rise in Many Gastrointestinal Cancers in Young People | Newswise  Newswise

Unlike the brain and spinal cord, peripheral nerve cells, whose long extensions reach the skin and internal organs, are capable of regenerating after injury. This is why injuries to the central nervous system are considered irreversible, while damage to peripheral nerves can, in some cases, heal, even if it takes months or years. Despite decades of research, the mechanisms behind peripheral nerve regeneration remain only partially understood.

Scientists have produced the first detailed characterization of the changes that weight loss causes in human fat tissue by analyzing hundreds of thousands of cells. They found a range of positive effects, including clearing out of damaged, aging cells, and increased metabolism of harmful fats.

Companies collaborate to offer AI powered assessment of biological age and cardiovascular risk from retinal scans. Longevity medicine platform Lifeforce … Continue reading "Lifeforce and Toku bring retinal scanning to longevity platform" The post Lifeforce and Toku bring retinal scanning to longevity platform appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

Walk through any trendy suburb and you might find a new "wellness" studio offering ice baths or "contrast therapy" (a sauna and ice bath combo).

A large prospective study published in Molecular Nutrition and Food Research reveals that a healthy plant-based diet is linked with a reduced risk of inflammatory bowel disease.

Research often points to exercise as a good way to boost mental health, but a recent study from the University of Georgia suggests that it's not just physical movement that affects mental health.

Research led by Naval Medical University's Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman with systemic sclerosis.

An increased amyloid-β load is not a benign result of aging; it is associated with lower cognitive performance and poor executive function in centenarians, a new study shows.

Following a ketogenic diet, modified alternate-day fasting, or late time-restricted eating leads to more weight loss than following the Mediterranean diet in adults with obesity.

This study reveals that adequate dietary fiber intake is crucial for lowering obesity risk and mortality, supporting its role in effective weight management.

Imagine farms bursting with life, soil getting richer every year, and water staying clean – that’s the promise of regenerative farming! It’s not just about growing...

Research in Health Economics indicates that introducing school grades—with A as the highest grade and F as a failing grade—at younger ages may negatively affect children's mental health.

Interest in the anti-parasitic drug ivermectin skyrocketed during the covid-19 pandemic, but evidence for many of its supposed health claims are lacking

A combination of high-resolution imaging and machine learning, also known as artificial intelligence (AI), can track cells damaged from injury, aging, or disease, and that no longer grow and reproduce normally, a new study shows.

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

For the first time, researchers have discovered and isolated adult stem cells from a non-human primate. This finding could transform the foundation for how we develop stem cell treatments.

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

Alina M Hernandez explains why the longevity industry is poised to revolutionize the course of human history. As an industry … Continue reading "Lifestyle, health literacy, behavior – driving the longevity space" The post Lifestyle, health literacy, behavior – driving the longevity space appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

Cynata CEO explains why standardized stem cell therapies could move from treatment to prevention in the fight against age-related decline. … Continue reading "Can stem cells tackle aging at scale? Cynata thinks so" The post Can stem cells tackle aging at scale? Cynata thinks so appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells. Functional rather than molecular This review begins with a note that its classifications focus […]

Research often points to exercise as a good way to boost mental health, but a recent study from the University of Georgia suggests that it's not just physical movement that affects mental health. It's how, where and why you exercise that makes the difference.

A study reveals that lysozyme (LYZ) plays a pivotal role in age-related blood vessel inflammation by influencing gut bacteria.

In a comprehensive Genomic Press Interview, postdoctoral researcher Dr. Mateus Vidigal de Castro shares his contributions to longevity research at the University of São Paulo.

A new machine learning approach identifies cellular senescence at single-cell resolution across varying cell types and tissue contexts, serving as a valuable tool to investigate tissue regeneration, aging, and progressive disease. The post AI Approach Tracks Cell Senescence Using Nuclear Morphology appeared first on GEN - Genetic Engineering and Biotechnology News.

Rejuvenation Research, Ahead of Print.

More and more men are investing in longevity — and for good reason. With a record 74% of U.S. adult males now taking dietary supplements, there’s growing awareness of the factors […] The post Best Anti-Aging Supplements for Men: What Really Works? first appeared on NOVOS.

For some people, the idea of liking exercise is laughable. Researchers in the UK have found that matching your workouts to your personality could make exercising more enjoyable. Regular physical activity can help prevent cardiovascular diseases, diabetes and certain types of cancer. In adults, physical exercise can also enhance well-being and reduce symptoms of depression […]

Mayo Clinic physician and researcher Dr. Abba Zubair's work combines two passions—medicine and space—for the benefit of astronauts and people on Earth. His research in space is yielding discoveries in cancer, stroke, bone loss and more.

While immunosuppressive medications are critical to preventing rejection of transplant organs, they also come with plenty of downsides. They can cause harsh side effects, like headaches and tremors, and increase the risk of infection and cancer. But what if there was a way to prevent organ rejection without using these medications?

A combination of high-resolution imaging and machine learning, also known as artificial intelligence (AI), can track cells damaged from injury, aging, or disease, and that no longer grow and reproduce normally, a new study shows.

A study led by Cambridge researchers has shed light on how neural stem cell grafts could help restore myelin in the central nervous system. The findings suggest that neural stem cell‐based therapies hold promise as a potential treatment for chronic demyelinating disorders, particularly progressive multiple sclerosis.

A study led by Cambridge researchers has shed light on how neural stem cell grafts could help restore myelin in the central nervous system.

Welcome to another edition of CEDARS/ASPENS Debates. CEDARS/ASPENS is a society of cornea, cataract and refractive surgery specialists, here to discuss some of the latest hot topics in ophthalmology.While endothelial keratoplasty (EK) has taken off and become the standard surgical procedure for decompensated corneas secondary to endothelial disease, there are new treatments on the horizon that are potentially safer and easier to perform, less invasive and more accessible. If these take off, EK may be significantly decreased or even eliminated in the future. Parag A. Majmudar, MD, and Jodi

Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem cell-derived hepatic organoids, report researchers from Japan. These three-dimensional liver organoids were capable of sustained, long-term proliferation while retaining hepatocyte-like features. Their findings could have the potential to drive future research on chronic liver disease and result in newer therapeutic approaches to treat it.

We are thrilled to announce the second edition of the International Longevity Summit (www.TransVisionMadrid.com) in beautiful Madrid after the major success in 2024. Organized by the Illustrious College […]

A burden of lingering senescent cells contributes to the chronic inflammation of aging and is disruptive to tissue structure and function. Excess visceral fat tissue is know to generate an increased burden of senescent cells. It does also dysregulate metabolism and provoke chronic inflammation in a range of other ways, however. So while senescent cells appear to be important in the damage done by obesity, it remains unclear as to what degree the use of senolytic drugs to selectively destroy senescent cells will reduce the consequences of obesity. Answers will emerge in time, but, as ever, making progress towards larger clinical trials and sufficient human data is a slow and expensive process. There is little incentive for industry to fund work on the existing cheap, […]

Japanese drugmaker Chugai is wading into the aging-related disease landscape, an area of drug R&D that’s gaining more traction among pharmaceutical giants. The Tokyo-headquartered company, part of the Roche family, will team up with the ...

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical organelles.

Hearing loss doesn’t just mute sound—it can muffle connection. A sweeping new study reveals that using hearing aids or cochlear implants not only improves communication but significantly reduces loneliness and social isolation. People with hearing devices reported richer relationships, stronger feelings of belonging, and even potential links to better cognitive health and longer lifespan. This [...]

The CHALLENGE trial in CRC studied structured exercise and demonstrated a DFS benefit comparable with or exceeding oxaliplatin chemotherapy.

Boosting Klotho protein levels in mice improves physical and cognitive aging, offering potential for future longevity therapies. A global research effort led by the Institut de Neurociències at the Universitat Autònoma de Barcelona (INc-UAB) has demonstrated that elevating levels of the Klotho protein in mice can extend their lifespan and enhance both physical and cognitive [...]

Besides humans, very few mammals receive care from their fathers. But when species do, it may benefit their children. New research from the University of Notre Dame found that the strength of early-life father-daughter relationships predicts meaningful differences in the survival of female baboons.

Scientists have discovered that starving and then refeeding worms can reveal surprising secrets about aging. When a specific gene (called TFEB) is missing, these worms don’t bounce back from fasting—they instead enter a state that looks a lot like aging in humans, with signs of stress and cell damage. This research gives scientists a simple but powerful way to study how aging begins—and how it might be stopped. Even more intriguing, the same process might help explain how some cancer cells survive treatment by going into a kind of sleep mode.

Chinese scientists who successfully restored damaged outer ears in mice said their findings proved the existence of a genetic switch for organ regeneration, which meant it might also be present in other organs. While the scientific journey to achieving organ regeneration in humans remains long and challenging, the study, published in the peer-reviewed journal Science, has offered the researchers hope. Last week, co-corresponding authors Wang Wei and Deng Ziqing published their findings that a...

Alzheimer's disease (AD) is a common, debilitating neurodegenerative disease affecting about 10 percent of people over the age of 65 and one third of people aged 85 and above. Besides environmental factors, the genes have a strong influence on whether or not a person develops AD during their lifetime.

Unlocking the secrets of your biological clock. Continue reading A single brain scan can now reveal how fast you’re aging on Tech Explorist.