Life Extension Technologies

Researchers here identify a common mechanism in the cellular responses to various forms of stress that appears to drive aspects of hematopoietic stem cell aging via impairment of mitochondrial function. Hematopoietic cells are responsible for generating immune cells and red blood cells. Aging produces alterations in the character and lineages of generated cells, contributing to dysfunction in the immune system and in platelet producing cells, among other issues. Suppressing some aspects of cellular stress responses, those that become maladaptive in the aged tissue environment, may prove to be useful as a basis for therapy. It nonetheless seems a poor alternative to instead repairing or otherwise addressing the forms of damage and dysfunction that provoke these excessive cell stress responses. Hematopoietic stem cells (HSCs) survive many […]

A host of positive "tipping points" can spark rapid nature recovery, a leading expert says. Action to protect and restore nature must accelerate radically to meet global goals for 2030 and beyond. Writing in the journal Nature Sustainability, Professor Tim Lenton says positive tipping points are key to achieving this.

Essay challenges the scientific validity of the Blue Zones concept and Ancel Keys’ Lipid Hypothesis, arguing that both rest on biased data, weak records, and methodological flaws. The authors say some longevity claims may reflect clerical errors, poverty, and unreliable vital records rather than uniquely healthy lifestyles.

A new study from the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University suggests that the children of a parent who lived to age 100 or older tend to have slightly healthier eating habits than those who do not come from such a robust lineage. The research offers one of the first comprehensive looks at the dietary habits of centenarian offspring, a group that shares roughly half of their parents' longevity genes and many years of their life environments.

By COPILOT Note from Vince Giuliano: As an experiment, I am publishing AI summaries of some of the most important already-published blog posts.  The idea is to convey the important content in a direct, shorter, clearer, easier-to-follow way.  This post … Continue reading →

The International Society for Stem Cell Research (ISSCR) has named CorEUstem COST Action and Stem Cell COREdinates as the recipients of the 2026 ISSCR Public Service Award.

Introduction The immune system is considered one of the most highly developed and sophisticated systems in the human body.  Significant age changes in immune function, termed immunosenescence, have been known for decades but only recently have studies revealed how such age changes can be minimized.  This blog will discuss the positive effects of exercise as … Continue reading Exercise – How to Retard Aging of the Immune System → The post Exercise – How to Retard Aging of the Immune System first appeared on Longevitybuilder.

A new research paper was published in Volume 18 of Aging-US on April 7, 2026, titled "Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration."

The International Society for Stem Cell Research (ISSCR) has submitted a formal response to a Request for Information (RFI) issued by the National Institutes of Health (NIH) regarding its pause on new submissions to the NIH Human Embryonic Stem Cell (hESC) Registry and considerations to reduce reliance on hESCs in federally supported research.

A major international study involving researchers from The University of Manchester has found that education is one of the strongest predictors of how long people live. Using a new statistical approach to overcome gaps in global data, the research shows that people with more education live significantly longer—even in countries where official records are incomplete. The research is published in the journal Demographic Research.

A new board aims to turn aging into a treatable target, using AI to move from reactive care to longer and healthier lives. What if medicine stopped chasing disease and started chasing time? For most of modern healthcare, the script has been predictable: wait for something to go wrong, then treat it. A diagnosis appears, […] The post Insilico forms industry’s first AI Longevity Board appeared first on Longevity.Technology.

New training marketplace pairs NUS rigor with Longevity Academy’s clinical pathways as longevity education matures. Following the recent launch of its Education and Training Marketplace, Longevity Clinics World is beginning to give the platform more defined shape – moving beyond the initial framing of a sector-wide knowledge gap and toward the practical question of how […] The post Longevity education finds its clinical footing appeared first on Longevity.Technology.

A new set of drugs exploit a recently-revealed weakness in 'zombie-like' – or senescent – cells that could lead to new treatments for cancer and age-associated diseases.

A flagship 900-acre farm in Herefordshire is being lined up as a testbed for the future of British agriculture, as the Duchy of Cornwall lau...

A clinical trial to reverse age-related vision conditions using stem cell treatment could finally deliver on the promise of a major discovery in ageing and regeneration made 20 years ago, says columnist Graham Lawton

Researchers at Hannover Medical School (MHH) have developed a method for the efficient production of human immune cells, such as macrophages, in medium-sized bioreactors. These immune cells can be derived from induced pluripotent stem cells and are important for disease research and the development of new therapeutic approaches. The method has now been published in the journal Nature Protocols.

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured type 1 diabetes in mice in a study by Stanford Medicine researchers. Type 1 diabetes arises when the immune system mistakenly destroys insulin-producing islet cells in the pancreas. None of the animals developed graft-versus-host disease—in which the immune system arising from the donated blood stem cells attacks healthy tissue in the recipient—and the destruction of islet cells by the native host immune system was halted. After the transplants, the animals did not require the use of the immune-suppressive drugs or insulin for the duration of the six-month experiment.

In a groundbreaking advancement poised to revolutionize the treatment of thoracic aortic aneurysm and dissection (TAAD), researchers have unveiled a novel stem cell approach involving CAR-CD34 (+) hematopoietic stem/progenitor cells produced in vivo. This innovative method, recently published in Nature Communications, presents an unprecedented opportunity to combat one of the most elusive and life-threatening cardiovascular […]

A gene therapy made by Regeneron is the first treatment of its kind approved for genetic hearing loss.

During a beautiful, abnormally warm February day this past winter, my two-year-old grandson was looking out the window and pointing at the heifers along my driveway and rambling about “da cows”. I decided to let him see them up close. Like most young, curious, and gentle cattle, they lined up shoulder-to-shoulder and slowly moved closer […] The post Regenerative Farms: Build It, Share It, Leave It appeared first on Understanding Ag.

Regenerative therapy is any treatment therapy that improves tissue health or function. With that definition, we can include platelet-rich plasma (PRP), stem cells, and autologous conditioned serum (ACS). The post Regenerative Medicine: Promise, Hype, and What Actually Works appeared first on GEN - Genetic Engineering and Biotechnology News.

In a groundbreaking study conducted at the Institute for Research in Biomedicine (IRB Barcelona), scientists have uncovered a remarkable phenomenon involving transfer RNA (tRNA) genes, which may reshape our understanding of molecular aging and cancer biology. This investigation, recently published in the prestigious journal Genome Research, reveals that tRNA genes, crucial translators of the genetic […]

For those of us in the Northern Hemisphere, spring is here. This is a time of renewal and hope for better times ahead, echoing what our field is trying to achieve: the rejuvenation of aging […]

For decades, the prevailing dogma in fitness circles has been that to build muscle strength and size, one must push their body to the absolute limit. The notion that only strenuous, exhausting workouts lead to meaningful muscle development has driven countless individuals into grueling gym sessions, often accompanied by significant soreness and fatigue. However, groundbreaking […]

Longevity Day at NFC Summit Lisbon has announced its confirmed speaker lineup ahead of its debut on 4 June 2026 at the Unicorn Factory in Lisbon. The event will bring together scientists, clinicians, founders, and investors […]

In a groundbreaking advancement in the treatment of mature T-cell and natural killer (NK) cell lymphomas, a newly published phase II clinical trial has demonstrated the promising therapeutic potential of allogeneic hematopoietic cell transplantation (allo-HCT). This study, recently unveiled in Nature Communications, heralds a new era that could substantially redefine the prognosis for patients afflicted […]

This study suggests exercise can mitigate cancer-related cognitive impairment, but combining it with ibuprofen offers no additional cognitive benefits.

Discovering he is getting old before his time, David Cox tries to lower his biological age by changing his diet in a helpful new book, The Age Code, says Graham Lawton

Until now, there have been few therapeutic options for children with severely reduced heart pump function. Recently, surgical constriction of the pulmonary artery has been introduced as an innovative approach to deliberately "train" the heart. Researchers at the University Hospital Bonn (UKB) and the University of Bonn investigated the underlying biological mechanisms of this approach.

A new meeting report was published in Volume 18 of Aging-US on April 6, 2026, titled "Toward actionable interventions in human aging (12th ARDD meeting, 2025)."

A Nature Medicine study found that healthy Australian adults were widely exposed to plastic-associated chemicals, with processed, packaged, and canned foods emerging as important modifiable contributors to urinary phthalate and bisphenol levels. In a 7-day pilot randomized trial, low-plastic food interventions reduced several urinary plastic-associated chemicals without lowering daily energy intake.

A groundbreaking study published in the Journal of the American College of Cardiology (JACC) has brought to light crucial insights into how fitness during midlife significantly impacts not only lifespan but also the quality of health in later years. This comprehensive observational cohort study followed over 24,500 adults, revealing compelling evidence that higher cardiorespiratory fitness […]

In a groundbreaking study illuminating the intricate genetic interplay underlying ageing and mortality, researchers have unveiled dynamic sex-specific trade-offs between body mass and lifespan in mice. This investigation, recently published in Nature, dissects the genetic loci that govern how somatic traits influence survival, revealing an elaborate genetic architecture that modulates ageing processes differently in males […]

In a groundbreaking stride toward addressing the dire scarcity of therapeutic options for pediatric patients suffering from severe cardiac dysfunction, researchers at the University of Bonn have unveiled a novel understanding of how early surgical interventions may ignite the heart’s intrinsic regenerative prowess. This revelation stems from meticulous investigations into pulmonary artery constriction—a surgical technique […]

Physical activity during pregnancy enhances the metabolic health of offspring, but new research in mice indicates that prenatal stress blunts these benefits, at least in male offspring.

Solar prominences mystery solved by new simulations. Continue reading Researchers investigated how solar prominences form and their secret to longevity on Tech Explorist.

Insilico Medicine, a clinical-stage generative artificial intelligence-driven biotechnology company, has formed what it describes as the industry’s first Longevity Board to provide scientific oversight and strategic guidance for AI-enabled aging research and drug discovery. The board will oversee life models, biomarkers of aging, the identification of dual-purpose targets implicated in aging, longevity, and disease, and […] The post Insilico forms longevity board to oversee AI aging research appeared first on Longevity.Technology.

The Gompertz law is a relatively simple equation that describes the exponentially increasing mortality rates observed in an aging population. One fits the equation to existing epidemiological data by adjusting the value of two parameters, α and β. Researchers here use the results of age-slowing interventions in large populations of nematode worms to assign physical, biological meanings to the changes in α and β produced by the treatment of aging. As the researchers describe here, β is related to length of time spent in poor health in later life, while α is related to length of time spent in good health in earlier life. In populations of many animal species, including humans, mortality rates increase exponentially with advancing age. The scale and rate of increase […]

How easily older adults can stand up from a chair may be a telling indicator of their overall quality of life.

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic manipulation.

New research suggests a high-salt diet may trick the immune system into prematurely aging the blood vessels, leading to cardiovascular decay.

New research has highlighted how inadequate environmental regulations and assessments of contaminated industrial land in India are endangering human populations and wildlife ecosystems.

Excessive daytime napping may signal health decline in older adults and is linked to higher mortality risk, a Mass General Brigham study suggests.

Human life expectancy has increased steadily over time since the 1800s, but much of the analysis is focused on life expectancy at birth, where the dominant effects involve improvements in early life survival. More interesting are the measures of remaining life expectancy at some adult age. These measures also increase over time, but more slowly. In recent decades, the increase in life expectancy at age 65 has increased at a pace that is on the order of one year in every ten. Since this happened over a span of time in which little to no meaningful progress was made in deliberately treating aging as a medical condition, it is reasonable to ask how it happened. As is usual in matters of human epidemiology, firm answers […]

New DEXA scan integration brings deeper, actionable insights into body composition to connected, physician-led care. Step on a scale and you get a number. Clean, simple, deceptively reassuring. But what if you’ve been told that number has always been a bit of a lie? It can’t tell you if you’re gaining muscle or quietly losing […] The post Hone Health adds DEXA scans to personalized longevity platform appeared first on Longevity.Technology.

At the forefront of biomedical innovation, the 12th Aging Research and Drug Discovery (ARDD) meeting, held at the University of Copenhagen, marked a pivotal shift in the field of aging biology. Convening a multidisciplinary assembly from academia, industry, and biotechnology sectors worldwide, the 2025 conference underscored a transformative vision: transitioning from descriptive studies of aging […]

NICE has recommended zanidatamab for HER2-positive biliary tract cancer in final draft guidance, offering patients more time and better quality of life.

A simple oral rinse may predict biological age, linking oral microbiome changes to aging, frailty, and chronic disease risk in a noninvasive manner.

Healthy diets spark lung cancer risk in non-smokers as pesticides loom  Fox NewsEating fruit is linked to lung cancer? Here’s what you need to know about that new study  The ConversationEating more fruits and vegetables tied to unexpected lung cancer risk  ScienceDailyStudy links fruit and vegetable-heavy diet with increased cancer risk  The IndependentStudy links lung cancer to eating fruits and veg: What this means  Medical News Today

Healthy diets spark lung cancer risk in non-smokers as pesticides loom  Fox NewsEating fruit is linked to lung cancer? Here’s what you need to know about that new study  The ConversationEating more fruits and vegetables tied to unexpected lung cancer risk  ScienceDailyStudy links fruit and vegetable-heavy diet with increased cancer risk  The IndependentStudy links lung cancer to eating fruits and veg: What this means  Medical News Today

The aging and longevity of flies is very dependent on intestinal function. The noted longevity-associated gene INDY acts on intestinal function, for example. Here, researchers report on their investigation of the role of the gut microbiome in INDY-related longevity in flies. As might be expected given the present state of knowledge of the role of the gut microbe in long-term health and aging, there are signs of a contribution. These results are only a first step, however; the gut microbiome is a complex array of different microbial species, and there is a great deal more that might be catalogued in terms of its relationship to genetic associations with longevity in this species. Reduction in the Indy (I'm not dead yet) gene, a plasma membrane citrate […]

King Charles commemorates Queen Elizabeth II's 100th birthday with a heartfelt tribute, reflecting on her legacy and expressing how today's world might have troubled her.

Nestlé and NTU Singapore today announced a multi‑year joint research partnership to advance the scientific understanding of how nutrition supports healthy longevity and women's health.

In a groundbreaking advancement in cancer care, researchers at the University of Rochester Medicine’s Wilmot Cancer Institute have uncovered promising evidence that a widely accessible over-the-counter anti-inflammatory medication, ibuprofen, can ameliorate cognitive impairments commonly experienced by cancer patients undergoing chemotherapy. This innovative approach emerges against a background of mounting interest in non-pharmacological interventions, such as […]

Absurdly bad study spurs headlines linking healthy diet to lung cancer  Ars TechnicaEating fruit is linked to lung cancer? Here’s what you need to know about that new study  The ConversationStudy links fruit and vegetable-heavy diet with increased cancer risk  The IndependentLung Cancer: Are Pesticides Driving Cases in People Under 50?  HealthlineScientists Reveal Eating Fruits and Vegetables May Increase Your Risk of Lung Cancer  SciTechDaily

Absurdly bad study spurs headlines linking healthy diet to lung cancer  Ars TechnicaEating fruit is linked to lung cancer? Here’s what you need to know about that new study  The ConversationStudy links fruit and vegetable-heavy diet with increased cancer risk  The IndependentLung Cancer: Are Pesticides Driving Cases in People Under 50?  HealthlineScientists Reveal Eating Fruits and Vegetables May Increase Your Risk of Lung Cancer  SciTechDaily

A groundbreaking study is underway at the University of Texas at Arlington, spearheaded by Kamal Awad, an assistant professor of research at the Bone-Muscle Research Center. This innovative research probes the intersection of cardiac and muscular decline associated with aging, a domain referred to as cardio-sarcopenia. It aims to unravel the complex biological interplay between […]

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic manipulation. The models were made at University of Michigan Engineering. Researchers at the Chinese Academy of Sciences provided monkey embryo data to help confirm that the Michigan team was indeed seeing a yolk-sac-like structure in their models. The work is published in the journal Nature Cell Biology.

For the first time in the realm of developmental biology, a groundbreaking stem cell model has astonishingly generated a structure analogous to the human yolk sac during early embryogenesis, originating from a single stem cell population without any genetic manipulation. This unprecedented achievement, realized by researchers at the University of Michigan Engineering, ushers in a […]

In 2025, Lara Weed and Jamie M. Zeitzer of Stanford University published an article linking the practice of seasonal time changes (Daylight Saving Time) to negative health outcomes, ranging from acute symptoms (heart attacks and strokes) to chronic conditions (obesity). Now, Professors José María Martín-Olalla (University of Seville) and Jorge Mira Pérez (University of Santiago de Compostela), after analyzing the methodology applied in that study, have concluded that "what the world read as scientific evidence against time change has turned out to be a mathematical illusion."

A known cell-death protein turns out to quietly reshape stem cell aging. As people grow older, the body’s ability to maintain healthy blood and a strong immune system gradually weakens. A major reason is the decline of hematopoietic stem cells (HSCs), which are responsible for producing all types of blood cells. Under normal conditions, HSCs [...]

Longevity is the next growth battleground – is your brand ready to compete? Join us in London for the Longevity Show preview breakfast: 28 April. As the 100-year life moves from theory to lived reality, longevity is no longer a niche wellness trend – it is a structural shift reshaping how people work, spend, save […] The post Are global brands and employers longevity-ready? appeared first on Longevity.Technology.

A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging These researchers […]

A major study presented today at ESCMID Global 2026 has found that antiretroviral therapy (ART) reduces accelerated biological ageing in people with HIV (PWH) by nearly four years, a finding that could transform how clinicians monitor HIV treatment and long-term health outcomes.

This year’s winners include hundreds of physicists across more than 30 institutions

Researchers at the University of Eastern Finland have identified a new geometric marker of the brain ventricles that could help predict which patients with idiopathic normal pressure hydrocephalus (iNPH) will benefit from shunt surgery, according to a recent study published in Fluids and Barriers of the CNS.

In a groundbreaking advancement illuminating the complex interplay between metabolic stress, inflammation, and ovarian aging, recent scientific investigations have spotlighted the receptor for advanced glycation end products (RAGE) as a pivotal molecular nexus. RAGE’s abnormal overexpression links chronic metabolic disturbances to accelerated ovarian senescence, driven by granulosa cell dysfunction, follicular depletion, and stromal fibrosis. This […]

“Cocaine hippos,” underground bees, and fresh insights into aging and heart health

In the rapidly evolving landscape of surgical care, the integration of enhanced recovery protocols is reshaping patient outcomes, particularly in the elderly population. A groundbreaking case report published in BMC Geriatrics by Ran and colleagues uncovers the profound potential of individualized Enhanced Recovery After Surgery (ERAS) protocols in managing complex surgeries for centenarians. This report […]

In full transparency, I’ve been a fangirl of Kara Swisher since I first read her work with Walt Mossberg and Recode, coinciding with my own work on the early adoption of the Internet in health care. Today, Swisher is everywhere all-at-once, covering technology, politics, and now, seeking truths about the so-called longevity economy.             Swisher appeared with Nicolle Wallace on her podcast, The Best People, on 13th April, so I was keen to tune in. The conversation covered a lot of ground, and it was Swisher’s take on science and health that I was most interested to hear. About 48 minutes into the session, Swisher provided the sound bite-insight I was seeking: that, “the #1 longevity hack is ‘don’t be poor.’” With my being a health economist advising the broad health ecosystem for 30-some years, Swisher was preaching something to this choir-of-one that I’ve known-I’ve-known for years: that the basic drivers of health are things outside of the

The remains of centenarian independence activist Lee Ha-jun, who fought under the 1910-1945 Japanese colonial rule, will return home this week from the United States to be laid to rest at a national cemetery, the veterans ministry said Monday. Lee, who took part in various independence movements, died at his home in California in February at the age of 104. He was the oldest surviving independence fighter living abroad. His remains will arrive at Incheon International Airport, Gyeonggi Province, on Tuesday ahead of a repatriation ceremony scheduled to take place at Seoul National Cemetery the following day. His remains will then be laid to rest at Daejeon National Cemetery, alongside his deceased wife. A total of 156 remains of independence fighters, including Lee, have returned home since a project to repatriate independence patriots began in 1946, according to the ministry. Only four surviving independence fighters remain in Korea.

In a groundbreaking study set to reshape our understanding of longevity, researchers Sarikaya Demirbas and Naharci have unveiled pivotal mortality predictors among community-dwelling centenarians via comprehensive geriatric assessments. As the global population ages and the number of centenarians rises, the scientific community eagerly seeks insights into the factors contributing not only to lifespan but also […]

A groundbreaking study unveiled at ESCMID Global 2026 in Munich has revealed that antiretroviral therapy (ART) has a profound impact on reducing the accelerated biological ageing associated with HIV infection. Researchers have demonstrated that, in people living with HIV (PWH), ART can reverse accelerated biological ageing by nearly four years, a discovery poised to revolutionize […]

Study links fruit and vegetable-heavy diet with increased cancer risk  The IndependentStudy links lung cancer to eating fruits and veg: What this means  Medical News TodayEating more fruits and vegetables could put you at risk for this cancer  The IndependentScientists Reveal Eating Fruits and Vegetables May Increase Your Risk of Lung Cancer  SciTechDailyLung Cancer: Are Pesticides Driving Cases in People Under 50?  Healthline

Study links fruit and vegetable-heavy diet with increased cancer risk  The IndependentStudy links lung cancer to eating fruits and veg: What this means  Medical News TodayEating more fruits and vegetables could put you at risk for this cancer  The IndependentScientists Reveal Eating Fruits and Vegetables May Increase Your Risk of Lung Cancer  SciTechDailyLung Cancer: Are Pesticides Driving Cases in People Under 50?  Healthline

A major study presented at ESCMID Global 2026 has found that antiretroviral therapy (ART) reduces accelerated biological aging in people with HIV (PWH) by nearly four years, a finding that could transform how clinicians monitor HIV treatment and long-term health outcomes.

A diet rich in fruit, vegetables and whole grains is generally recommended for better health and to lower the risk of cancer and other diseases.

A nasal spray using extracellular vesicles can reduce brain inflammation, restore cell function, and improve cognition, offering a potential breakthrough in reversing brain aging. Think of the brain less like a machine that simply wears out and more like one that gradually overheats. As people age, low-level inflammation builds up in key regions tied to [...]

When their queen dies, naked mole rat females usually wage bloody battles of succession. But peace may be possible, a new study suggests

The larynx, also known as the voice box, is home to the vocal folds and is the reason people can talk and sing while manipulating pitch and volume. The vocal folds are covered with mucosa, or mucous membranes.

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

A new study published today in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death.

Fewer than 10 people worldwide have eradicated the virus with stem cells. But this case was special—no one knew his brother's cells carried a protective mutation until transplant day. The post Norwegian Man Cured of HIV by His Brother’s Stem Cells appeared first on SingularityHub.

In a groundbreaking investigation poised to reshape nutritional recommendations for older adults, a new study has revealed a compelling relationship between adherence to the Mediterranean diet and the incidence of dyspeptic symptoms in elderly populations. Conducted by Otay Lule, N., Lule, K.O., and Ozturk, Z.A., the research delves deep into how dietary patterns can influence […]

In the relentless battle against breast cancer, the challenge of preventing tumor recurrence after surgical intervention has remained a formidable obstacle. Traditionally, post-surgical chemotherapy and tissue reconstruction have often been compromised by the limitations of scaffold-based materials that fail to integrate seamlessly with native tissues or degrade at a pace compatible with tissue regeneration. However, […]

Restricting calorie intake in species such as mice, rhesus monkeys, and fruit flies has been shown to extend their lifespans. In some cases, these animals not only live longer, but are also free of disease. But when pushed too far, calorie restriction can have negative impacts. Mice that undergo a 40% reduction in calorie intake, for example, are more susceptible to infections, less likely to reproduce, and experience stunted growth.

The National Institute on Aging's Interventions Testing Program (ITP) is the full stop at the end of many a debate over the merits of development of one substance or another as a hoped for treatment to modestly slow aging. The ITP uses a very large number of mice and considerable rigor to assess effects on life span. The program typically focuses on small molecules and supplements that have prior evidence for anti-aging effects, and usually those with a long history in the literature. Given the number of compounds that show no effect on life span in the hands of the ITP, this initiative serves as a reminder that any one study in a hundred mice that demonstrates modest slowing of aging does not in fact […]

In the quest to unravel the mysteries of aging, blood has emerged not just as a biomarker reflecting the passage of time but as an active player capable of modulating the aging process itself. A groundbreaking study recently published in Experimental & Molecular Medicine sheds light on the intricate mechanisms by which blood influences aging […]

Two previously unknown stem cell types appear to play a central role in children's height growth, according to a study from the University of Gothenburg. The study also shows that growth hormone can act directly on these cells.

Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight […]

From encapsulated cell therapies to gene-driven breakthroughs, a new wave of biotech is targeting the biology of aging. Heart disease, diabetes, Alzheimer’s – each treated as its own battle. Aging, meanwhile, sat in the background, accepted but not addressed, but that perspective is starting to feel outdated. A new wave of biotech companies is asking […] The post Biotechs race to turn aging science into cell-based therapies appeared first on Longevity.Technology.

Oral combination therapy boosts lifespan 33% and slows frailty, pointing to a more holistic approach to aging. What if the reason we haven’t “solved” the mysteries of aging yet is that we’ve been treating it like a single disease? That’s the question underneath new data from Seragon Biosciences, which has just published preclinical results on […] The post New longevity drug SRN-901 shows 33% lifespan boost appeared first on Longevity.Technology.

One of the major projects within the study of comparative biology is the attempt to understand why adult individuals of some species can fully regenerate lost tissues following injury, while mammals such as our own species cannot. A variety of modest inroads into identifying potentially important differences in cellular biochemistry and activity have been made, such as work focused on senescent cells and macrophages, but it remains an unsolved challenge. Researchers here present more data to add to that already under consideration, focused on the role of oxygen sensing in the initial response to injury. It is unclear as to whether it can lead to dramatic improvements in mammalian regeneration, but the work suggests that regeneration could be improved via manipulation of oxygen sensing in […]

Humans, and most other mammals, exhibit a common set of differences between males and females in the trajectory of aging and age-related disease. Females live longer, but with greater disability, for example. Dive deeper to look at the fine details of specific tissues and biological systems, and the list of differences expands. Researchers here report on their assessment of differences between men and women in the aging of the immune system, for example. While interesting, it isn't clear that differences in the progression of aging will be all that important in a future of effective rejuvenation therapies. It is certainly possible that any given narrow approach to rejuvenation that targets just one mechanism of aging will prove to be more or less effective to some […]

Ultra-processed food diets may impair muscle health, with MRI findings showing increased fat infiltration in individuals at risk for knee osteoarthritis.

The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing there. If this technique […]

The Asia-Pacific Longevity Medicine Society (APLMS), in partnership with The Kitalys Institute, announced that the 2026 Asia-Pacific Healthy Longevity International Summit (APAC-LMIS) will […]

What do sheep, regeneration of Maine farmland, and indigenous knowledge have to do with one another? Quite a bit, when it comes to Melissa Schneider, shepherd and landowner of Casa Portal. Along with herding and sustainable land management, Melissa is one of many women farmers who are staking their place. The post On a Maine Farm, Regeneration Starts With the Sheep appeared first on Modern Farmer.

A new gene‑editing strategy programs hematopoietic stem cells to produce therapeutic antibodies and other proteins. The approach generates long‑lasting immunity in mice and could point to single‑vaccine treatments for diverse diseases in the future. The post Stem Cell Editing Programs the Immune System to Make Own Therapeutic Proteins appeared first on GEN - Genetic Engineering and Biotechnology News.