BioTech Review

The axonal connections between neurons are sheathed in myelin, which acts as an insulator to enable the propagation of electrical impulses along the axon. Like all molecular structures in the body and brain, myelin sheathing is subject to ongoing damage and must continually be maintained in order to prevent dysfunction in the nervous system. A population of cells known as oligodendrocytes undertakes this task. Conditions in which excessive loss of myelin occurs, such as the autoimmune condition multiple sclerosis, are particularly debilitating. But a lesser degree of myelin damage occurs to everyone in old age, in part due to reduced oligodendrocyte function, and this damage contributes to cognitive impairment. Thus it is interesting to keep an eye on that part of the research community focused […]

In a landmark discovery, researchers from QIMR Berghofer in collaboration with the Francis Crick Institute, have unlocked the secrets of how brain stem cells enter and exit a resting state called "quiescence"—a process with roots stretching back to the dawn of life. Their findings, published in Science Advances, may lead to new approaches in brain health and cancer therapy.

Metagenomi Inc. (NASDAQ:MGX) is one of the best young stocks to buy and hold for 5 years. In mid-May, Metagenomi announced the presentation of 3 abstracts at the American Society of Gene & Cell Therapy/ASGCT 28th Annual Meeting, which was held from May 13 to 17 in New Orleans, Louisiana. The presented data highlighted Metagenomi’s […]

A glucose-sensitive nanovaccine delivers CRISPR to tumors, silences immune-suppressing genes, and activates a targeted immune response against cancer.

Researchers from QIMR Berghofer in collaborat ion with the Francis Crick Institute, have unlocked the secrets of how brain stem cells enter and exit a resting state called ‘quiescence’ - a process with roots stretching back to the dawn of life. Their findings may lead to new approaches in brain health and cancer therapy.

Modern dairy cows are milk-producing powerhouses—some yielding more than 50 kg a day. But all that productivity comes at a price: their mammary glands often suffer from inflammation and cellular stress, which not only reduces milk quality but also affects the cows' well-being.

A newly created cell model of the amniotic sac could reveal new insights into early pregnancy, as well as generate helpful products for medical use.

Nerve cells are not just nerve cells. Depending on how finely we distinguish, there are several hundred to several thousand different types of nerve cell in the human brain according to the latest calculations.

The skin has two types of adult stem cells: epidermal and hair follicle. Their jobs seem well-defined: maintaining the skin, or maintaining hair growth. But as research from Rockefeller University has shown, hair follicle stem cells (HFSCs) can switch teams, pitching in to heal the skin when it receives an injury. How do these cells know it's time to pivot?

The Canadian government is currently considering approving the entry of gene-edited pigs into the food system.

CZI and the Innovative Genomics Institute announce the funding of the Center for Pediatric CRISPR Cures which will use CRISPR-based editing technology to advance cures for severe pediatric genetic diseases. The post Center for Pediatric CRISPR Therapies Founded by IGI, CZI appeared first on GEN - Genetic Engineering and Biotechnology News.

Researchers have developed a new gene-editing platform that will enable safer and more effective T cell–based immunotherapies to treat cancer.

CRISPR Therapeutics AG (NASDAQ:CRSP) is one of the 10 Stocks Going Wild. Crispr Therapeutics rallied for a second day on Wednesday, adding 9.6 percent to close at $60.08 apiece, tracking the rally in the biotechnology sector and the broader market. During the session, the biotechnology industry rose by 3.58 percent amid a flurry of developments […]

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

A new process could help to treat liver disease without needing an organ transplant, a new study reveals.

Source: National Library of Medicine - Related MedlinePlus Pages: Genes and Gene Therapy

CZI and the Innovative Genomics Institute announce the funding of the Center for Pediatric CRISPR Cures which will use CRISPR-based editing technology to advance cures for severe pediatric genetic diseases. The post Center for Pediatric CRISPR Therapies Funded by IGI, CZI appeared first on GEN - Genetic Engineering and Biotechnology News.

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight-loss drugs, doing away with injections in favor of a one-time treatment.

Would you get a one-time genetic modification such that you'd never have to take a GLP-1 drug for weight loss ever again?

McGill researchers at TissueTinker are 3D printing tumors for cancer research to help refine treatment options for patients.

Lipid nanoparticles (LNPs) were used to deliver genome editing tools that enabled mice to produce a therapeutic weight-loss peptide from their own livers, suppressing weight gain and improving glucose control for months. The post Obesity Reversed in Genome Edited Mice that Produce Their Own GLP-1 appeared first on GEN - Genetic Engineering and Biotechnology News.

Research led by Naval Medical University's Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman with systemic sclerosis.

Researchers create a one-time genome editing introducing a GLP-1 receptor agonist, resulting in long-term appetite suppression, weight loss, and blood sugar control in mice.

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight-loss drugs, doing away with injections in favor of a one-time treatment.

The herpes simplex virus type 1 (HSV-1), which affects almost two-thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.

Scientists seeking to make personalized gene editing therapies a reality for more people have launched a new initiative to develop cures for the rarest of diseases left behind by drug companies. ...

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

For the first time, researchers have discovered and isolated adult stem cells from a non-human primate. This finding could transform the foundation for how we develop stem cell treatments.

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

Cynata CEO explains why standardized stem cell therapies could move from treatment to prevention in the fight against age-related decline. … Continue reading "Can stem cells tackle aging at scale? Cynata thinks so" The post Can stem cells tackle aging at scale? Cynata thinks so appeared first on Longevity.Technology - Latest News, Opinions, Analysis and Research.

A Ph.D. student in biomolecular engineering at the University of California, Santa Cruz, has built a software program designed to facilitate the kind of precision genome editing involved in the development of cutting-edge therapeutics for genetic conditions such as certain metabolic or blood disorders, like sickle-cell anemia.

Personalized CRISPR cures for children born with rare genetic diseases are now a step closer to being more widely available.

The center will bring custom gene-editing treatments to children.

Fourteen million people worldwide suffer from enlarged hearts, or hypertrophic cardiomyopathy (HCM), a genetic disease that thickens the heart's walls, making it harder for the organ to pump blood - but many of them don't know it.

By Dr. Mercola If you've ever had qualms about eating genetically modified (GM) foods, you'd likely be deeply concerned about receiving a GM vaccine as well. Such vaccines are already being produced – some are even on the U.S. Centers for Disease Control and Prevention's (CDC) recommended vaccine schedule – even though, as is the case with GM foods, we know very little about their long-term effects. In the interview above, Vicky Debold, PhD, RN, director of research and patient safety with the National Vaccine Information Center (NVIC), spoke with me about the many reasons to be very wary of this new technology, which is far more intertwined with other biotech "innovations," like GM food, than you might think. Nobody Knows What Happens When You Inject People with GM Vaccines There have been some fair warnings, though. In 2006, researchers wrote in the Journal of Toxicology and Environmental Health: 1 "Genetically modified (GM) viruses and genetically

New research has found a novel target with therapeutic potential for metastatic eye melanoma—an aggressive eye cancer—with implications for a range of other cancers.

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical organelles.

A new way to grow stem cells may help them release more of the signaling proteins they use to repair tissue, potentially improving future treatments.

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical organelles. Their findings, published in Cell, add to fundamental knowledge about the role of mitochondria in cells and evolution and could eventually lead to new treatments for patients with mitochondrial diseases such as Leigh syndrome and Kearns-Sayre syndrome, which can affect numerous organ systems.

New drugs that target "zombie" tuberculosis (TB) cells are now a step closer, thanks to a new study led by the University of Surrey, published in Scientific Reports.

CRISPR Therapeutics AG (NASDAQ:CRSP) ranks among the best CRISPR stocks to buy. Following CRISPR Therapeutics AG (NASDAQ:CRSP)’s supplemental update to its Phase 1 CTX310 trial findings, H.C. Wainwright reaffirmed its Buy rating and $65 price target on the company on June 27. According to the latest results, CTX310, an in vivo ANGPTL3 knockout therapy, continues […]

Scientists at the University of Hong Kong have started experimenting with 3D printed organ technology to help burn victims.

Editas Medicine, Inc. (NASDAQ:EDIT) ranks among the best CRISPR stocks to buy. At the European Hematology Association 2025 Congress on June 12, Editas Medicine, Inc. (NASDAQ:EDIT) revealed new in vivo data showing notable progress in gene editing for beta thalassemia and sickle cell disease. According to the study, a single dose of the company’s proprietary […]

A study published in Cell Stem Cell reveals that some mutations in blood stem cells might help protect against late-onset Alzheimer's disease.

Scientists at The Jackson Laboratory (JAX) have developed mouse models that survive premature death and enable pre-clinical testing of alternating hemiplegia of childhood (AHC), a devastating and sometimes fatal neurological disorder that affects about one in a million children with no current treatment.

Many companies are working on platforms or processes that bring adaptability to bioprocessing. That should drive the approval of more therapies. With more flexibility in bioprocessing platforms, even more cell and gene therapies might be approved. The post Modular Bioprocess Platforms for Gene-Edited Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.

Scientists from QIMR Berghofer's Cardiac Bioengineering Lab have developed lab-grown, three-dimensional heart tissues known as cardiac organoids that mimic the structure and function of real adult human heart muscle.

Plant scientists have used a standard "gene gun" since 1988 to genetically modify crops for better yield, nutrition, pest resistance and other valuable traits.

Genome editing technologies like CRISPR-Cas9 have transformed biology, medicine, and agriculture, but concerns remain about unintended edits at off-target DNA sites. These off-target effects can cause harmful mutations and are difficult to predict, as they depend not only on the guide RNA but also on an organism's unique genetic makeup. Most existing prediction tools rely on a standard reference genome, ignoring key variations like SNPs, insertions, and deletions that differ across individuals and alleles.

In recent years, the revolutionary gene-editing technology CRISPR-Cas9 has emerged as a powerful tool set to transform medicine, agriculture, and biological research. Despite its immense promise, one of the most persistent challenges facing CRISPR-based interventions is the accurate prediction and minimization of off-target effects—unintended alterations to the genome that can have deleterious consequences. These inadvertent […]

In a groundbreaking advancement poised to revolutionize the field of gene editing, researchers have unveiled a near-infrared (NIR) light activatable chemically induced CRISPR system, marking a pivotal step toward precise, spatiotemporal control of genome engineering. This innovative platform widens the horizons of CRISPR technology by merging the unparalleled specificity and efficiency of CRISPR-Cas systems with […]

Source: National Heart, Lung, and Blood Institute - Related MedlinePlus Pages: Cystic Fibrosis

The NATO Innovation Fund (NIF) has made its first investment in a biotechnology startup. The alliance’s VC arm announced today that it’s co-leading a $35mn Series A round for UK-based Portal Biotech as it seeks to strengthen NATO’s defences against biological warfare. Portal develops portable, AI-powered diagnostic devices capable of detecting pathogens at the single-molecule level. Unlike traditional lab-based systems, its platform is designed for field deployment. It aims to offer rapid, on-site identification of biological threats.  Ana Bernardo-Gancedo, senior associate at NATO Innovation Fund, told Reuters that this capability is crucial for defence and security. “We believe it is…This story continues at

On this GEN Live, we take a close look at the work behind this successful treatment and perhaps more importantly, we explore how this can be done on a larger scale in the future. The post Beyond Baby KJ: Next Steps in Manufacturing Genome Editing Cures appeared first on GEN - Genetic Engineering and Biotechnology News.

In this article, we will take a look at the Top 10 CRISPR Stocks to Buy Now. Innovation is a hallmark of the biopharmaceutical sector, which is fueled by the demand for novel therapies to address unresolved medical needs. Gene editing and gene therapy are two of the sector’s most pivotal developments, with CRISPR-Cas9 at […]

In a groundbreaking advancement destined to reshape the future of organ transplantation, an international team of researchers has unveiled unprecedented insights into the immune dynamics following pig-to-human kidney xenotransplantation. Presented at the prestigious European Society for Organ Transplantation (ESOT) Congress 2025 in London, this pioneering study delves deep into the cellular interplay that underpins the […]

A pioneering study has provided unprecedented insights into the immune response following pig-to-human kidney xenotransplantation. The findings, presented today at the ESOT Congress 2025, mark a significant step forward in overcoming the biggest challenge in xenotransplantation: rejection by the human immune system.

The mystery of how human breast milk is synthesized within the mammary gland has long intrigued scientists, yet surprisingly, it remains vastly underexplored. Now, a groundbreaking study from ETH Zurich, led by Professor Marcy Zenobi-Wong’s team specializing in Tissue Engineering and Biofabrication, promises to reshape the way researchers understand lactation. By developing minuscule, three-dimensional replicas […]

In a first step toward FDA approval of kidney xenotransplantation, a living human with end-stage kidney disease may receive a pig organ as soon as this summer as part of a clinical trial program approved by the agency in February.If results are positive, xenotransplantation — transplanting a non-human organ into a human — could become a plausible solution to the shortage of human kidneys available for transplant from living or deceased donors, according to experts who spoke with Healio.“I think over the next 10 years we will see xenotransplantation widely available, and we

This week we spoke to Humacyte founder, Laura Niklason about the real-world applications for lab-grown blood vessels in conflict zones. The post Humacyte: Saving lives with lab-grown blood vessels in conflict zones appeared first on Labiotech.eu. © Labiotech UG and Labiotech.eu. Unauthorized use and/or duplication of this material without express and written permission from this site’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Labiotech UG and Labiotech.eu with appropriate and specific direction to the original content.

Chinese researchers have made a major advance in the science of gene editing by developing a new way to treat diseases that cannot be cured through existing methods. Their new gene editing tools, known as mitochondrial DNA base editors, can fix errors in the DNA inside a cell’s mitochondria. The scientists used these editors to create rats with diseases caused by these mitochondrial DNA errors and succeeded in making the first direct corrections of these flaws in animals. These mitochondrial DNA...

In a groundbreaking advancement poised to revolutionize the future of crop genetic engineering, scientists have unveiled a novel method for delivering CRISPR–Cas9 genome-editing tools into wheat plants using an RNA virus-based vector. This technological breakthrough addresses a major bottleneck in plant biotechnology — the efficient and heritable delivery of gene-editing components into monocot species, which […]

In the ever-evolving field of plant biotechnology, a revolutionary approach known as Virus-Induced Gene Editing (VIGE) has emerged as a beacon of transformative potential. Traditionally shadowed by the dominance of tissue-culture-mediated transgenesis, VIGE represents a paradigm shift that promises to rewrite the rules of plant genome engineering. For years, the allure of VIGE lay in […]

In medically indicated weight loss, attention is typically focused on the associated health benefits. However, recent research findings suggest that recovery from obesity-induced systemic inflammation may take several years.

We came across a bullish thesis on CRISPR Therapeutics AG (CRSP) on Two Natural Cap’s Substack. In this article, we will summarize the bulls’ thesis on CRSP. CRISPR Therapeutics AG (CRSP)’s share was trading at $41.52 as of 11th June. CRSP’s trailing and forward P/E were 22.55 and 23.36 respectively according to Yahoo Finance. CRISPR has re-entered […]

In a groundbreaking advancement that could redefine the future of mitochondrial medicine, scientists from the Netherlands have harnessed the precision of mitochondrial base editing to correct deleterious mutations in human cells. This remarkable achievement, detailed in the open-access journal PLOS Biology on June 24, marks a pivotal step toward treating a broad spectrum of mitochondrial […]

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The results, published in the open-access journal PLOS Biology, offer new hope for people with rare genetic conditions.

Mikael Dolsten, Pfizer's former chief scientific officer who led the company’s Covid-19 vaccine development, has joined the board of Arbor Biotechnologies, a gene editing startup working on therapies for liver and neurological diseases, Arbor told ...

A recent study investigated the effect of a single treatment of prostaglandin E2 on improving muscle strength and rejuvenating muscle stem cells in mice. The researchers explored the molecular and epigenetic aspects underlying this rejuvenation [1]. Aging muscle […]

Using gene editing in a preclinical model, researchers at UT Southwestern Medical Center blocked the symptoms of a rare smooth muscle disease before they developed. Their findings, published in Circulation, could eventually lead to gene therapies for this and other genetic diseases affecting smooth muscle cells.

Crops poised to be grown in England but renegotiation of trade agreement with EU could complicate matters

While some scientists argue that agricultural gene editing regulations are overly restrictive, a new paper from the University of Adelaide emphasizes the importance of clear regulations to ensure that new technologies are used safely and responsibly.

Scientific organizations recently called for a 10-year ban on human germline editing. But will we ever be ready? And how would we even know?

Mesenchymal stem cells (MSCs), which can be harvested from fat and bone marrow, have immune-modulating and anti-inflammatory effects that are beneficial for both human and veterinary medicine.

Mesenchymal stem cells (MSCs), which can be harvested from fat and bone marrow, have immune-modulating and anti-inflammatory effects that are beneficial for both human and veterinary medicine. However, MSCs have a limited proliferation capacity, with their quality varying depending on the donor's age and where they were harvested from.

A dramatic pullback in public biotech investment catalyzed by economic and regulatory upheaval is putting even more stress on startups navigating a yearslong downturn.

A breakthrough in veterinary regenerative medicine has been achieved with the successful generation of mesenchymal stem cells (MSCs) derived from canine induced pluripotent stem cells (iPSCs). Researchers at Osaka Metropolitan University have pioneered a refined method to produce high-quality canine MSCs that promise to revolutionize treatments for a wide range of diseases in dogs, pushing […]

In a landmark advancement that could revolutionize colorectal cancer treatment, researchers have developed a pioneering organoid model derived from colorectal cancer cell lines, embodying stem cell-like characteristics that faithfully replicate the regrowth properties of residual cancer cells following neoadjuvant chemotherapy. This innovative model offers unprecedented insights into the elusive biology of cancer persistence and recurrence, […]

Using a newly devised, three-dimensional model to study the regeneration of nerve tissue in the nose, researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) and colleagues have discovered that one type of stem cell thought to be dormant may play a more significant role in preserving the sense of smell than originally believed.

Objective Biotechnology, a pioneer in nextgeneration research tools, today announced the commercial launch of the Autoinjector, the first fully automated robotic system for microinjection in genetic research.

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows. The findings, published in Nature Biotechnology, could lead to new therapies for a variety of genetic diseases that affect multiple organs.

The promise of genome editing to help understand human diseases and create new therapies is vast, but technological limitations have limited advancement of the field.

The rapid evolution of genome editing technologies has ushered in an era where the potential to understand and treat human diseases appears nearly limitless. Recent advancements, particularly in the realm of multiplexed editing, promise to push the boundaries of what is possible within genetic research and therapy. Traditional gene editing methods, including the widely recognized […]

Researchers from the Lawrence Berkeley National Laboratory (Berkeley Lab), UC Irvine, and the University of Illinois Urbana-Champaign (UIUC), have used biology to convert human urine into a valuable product. The team genetically modified yeast to take the elements present in urine and create hydroxyapatite—a calcium and phosphorus-based mineral naturally produced by humans and other animals to build bones and teeth.

Last spring, Xaira Therapeutics launched with over a billion dollars, a star-studded team and big dreams to remake R&D with AI. The South San Francisco-headquartered startup has been fairly quiet since its ...

The deal centers around a medicine that could “shift the treatment paradigm for cardiovascular disease,” Lilly said, but also follows a yearslong in decline in Verve’s share price amid skepticism over the need for such a therapy. 

Eli Lilly said Tuesday that it will acquire Verve Therapeutics, a biotech developing gene-editing therapies for cardiovascular disease.

It appears that Eli Lilly couldn’t wait to get its hands on Verve Therapeutics’ PCSK9 program. Lilly said Tuesday that it will buy the gene editing biotech for about $1 billion at $10.50 per share ...

Tokyo, Japan (SPX) Jun 17, 2025 Imagine living and working hundreds of miles above Earth for more than 50 days. That has been the reality for China's Shenzhou XX crew-Chen Dong, Chen Zhongrui, and Wang Jie-currently aboard the Tiangong Space Station conducting vital scientific and medical research. In a video released Monday by China Central Television (CCTV), the astronauts were shown carrying out a full slate of experi

Researchers have investigated a never-before-used method of transfecting senescent mesenchymal stem cells (MSCs) and published their results In the Cell journal Molecular Therapy Nucleic Acids. Detergents for gene […]

He Jiankui looked a little tired and worn as he contemplated his future. With no home and no institution to host his research, the 41-year-old biophysicist and self-proclaimed “pioneer of gene editing” was weighing up what to do next while staying at an upmarket hotel in Beijing late last month. He, who caused a global uproar in 2018 with his announcement of the world’s first gene-edited babies, planned to move to the United States to continue his research into gene-editing embryos to combat...

A team at Kobe University has created a game-changing resource for autism research: 63 mouse embryonic stem cell lines, each carrying a genetic mutation strongly associated with the disorder. By pairing classic stem cell manipulation with precise CRISPR gene editing, they ve built a standardized platform that mirrors autism-linked genetic conditions in mice. These models not only replicate autism-related traits but also expose key dysfunctions, like the brain s inability to clean up faulty proteins.

Blood vessels are essential to nearly all tissues, delivering nutrients and oxygen, regulating hemostasis, and modulating inflammation.

A legal scholar with a doctorate in wildlife genetics explains the promise biotechnology techniques hold for some animals that are currently endangered.

There are more than 100,000 people on organ transplant lists in the U.S., some of whom will wait years to receive one – and some may not survive the wait. Even with a good match, there is a chance that a person's body will reject the organ.