BioTech Review

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

Using genome‑wide CRISPR activation and knockout screens in primary human T cells, researchers mapped the human genes that shape HIV infection and identified potent antiviral factors, including PI16 and PPID, with distinct mechanisms of action. The post CRISPR Screens Map Human T‑Cell Genes That Promote or Block HIV Infection appeared first on GEN - Genetic Engineering and Biotechnology News.

Scientists at Johns Hopkins Medicine have unveiled pioneering research demonstrating the potential of patient-derived brain organoids in advancing Alzheimer’s disease treatment and diagnosis. These intricate, lab-grown clusters of brain tissue, developed from the induced pluripotent stem cells (iPSCs) of Alzheimer’s patients, represent a groundbreaking platform to explore the disease’s pathology at an unprecedented molecular level. […]

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic manipulation. The models were made at University of Michigan Engineering. Researchers at the Chinese Academy of Sciences provided monkey embryo data to help confirm that the Michigan team was indeed seeing a yolk-sac-like structure in their models. The work is published in the journal Nature Cell Biology.

In a groundbreaking development poised to revolutionize the field of gene editing and regenerative medicine, researchers have unveiled a novel photoactivatable CRISPR/Cas13d system that employs upconversion nanoparticles for precise RNA engineering deep within living tissues. This cutting-edge technology, detailed in a 2026 publication in Nature Communications, proposes a significant leap forward in the treatment of […]

Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells. Now, a team of scientists from Wageningen University & Research and Van Andel Institute has identified a way to exploit this distinction. Using a variant of CRISPR, a modern tool for editing DNA, they distinguished tumor DNA from healthy DNA and selectively cut only the former. The study, published today in Nature, is an early but promising step toward a cancer therapy that targets and destroys tumor cells with high precision.

Dr. Swee Lay Thein and Dr. Stuart Orkin won the $3 million Breakthrough Prize in Life Sciences for their work toward a functional cure for the deadly blood disorders sickle cell disease and beta thalassemia.

Fewer than 10 people worldwide have eradicated the virus with stem cells. But this case was special—no one knew his brother's cells carried a protective mutation until transplant day. The post Norwegian Man Cured of HIV by His Brother’s Stem Cells appeared first on SingularityHub.

Researchers have developed a modified version of the CRISPR gene-editing tool that in early laboratory experiments suggests it may have the potential to “silence” the extra...

Two previously unknown stem cell types appear to play a central role in children's height growth, according to a study from the University of Gothenburg. The study also shows that growth hormone can act directly on these cells.

Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight […]

Long-term in vivo production of therapeutic proteins and development of vaccines that elicit protective levels of broadly neutralizing antibodies (bNAbs) against major pathogens face challenges. In this study, we report on an alternative gene editing ...

Why does the same genetic mutation cause a severe brain malformation in some patients but not in others? Researchers from the MOSAIC team at the Paris Brain Institute have developed mosaic human cortical organoids carrying mutations in the DEPDC5 gene in order to model focal cortical dysplasia—a brain malformation responsible for drug-resistant epilepsy in children.

Olivia Poh / Bloomberg: Canva unveils Canva AI 2.0, which can generate editable layered designs from conversational prompts using Canva's foundation model built specifically for design  —  Australia's highest-profile tech unicorn is undertaking a risky transformation as it seeks to prove its relevance in the age of generative AI.

Researchers at Karolinska Institutet and KTH Royal Institute of Technology in Sweden have developed an improved method for creating insulin-producing cells from human stem cells. The results, published in Stem Cell Reports, demonstrate that these cells effectively regulate blood sugar levels in laboratory tests and can reverse diabetes in mice.

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.

In a groundbreaking collaborative effort, researchers from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have unearthed a critical vulnerability within the cellular machinery of RAS-driven cancers—one that holds the promise of transforming therapeutic approaches for some of the most aggressive and treatment-resistant tumours. This discovery centers on the spliceosome, an essential […]

Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells. Now, a team of scientists from Wageningen University & Research and Van Andel Institute has identified a way to exploit this distinction. Using a variant of CRISPR, a modern tool for editing DNA, they distinguished tumor DNA from healthy DNA and selectively cut only the former.

Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells.

In a pioneering breakthrough that could revolutionize cancer therapy, researchers from Wageningen University & Research and Van Andel Institute have unveiled a novel gene-editing approach that exploits subtle chemical nuances distinguishing tumor DNA from healthy DNA. This innovative method leverages a unique variant of the CRISPR gene-editing system known as ThermoCas9 to selectively target and […]

Beeline Medicine is focused on development of five inflammatory and immune disorder drugs, starting with a potential daily pill for lupus.

A newly characterized Cas12f nuclease shows strong editing in human cells. Researchers engineered a variant with markedly improved efficiency, advancing efforts toward compact genome editors suitable for targeted delivery. The post Engineered Miniature CRISPR Boosts Gene‑Editing Efficiency in Human Cells appeared first on GEN - Genetic Engineering and Biotechnology News.

The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the emphasis has been on its underlying mechanisms and nucleases. In contrast, little research has examined how CRISPR-Cas systems have evolved and been optimized. In collaboration with the universities of Leipzig, Freiburg, and Michigan (U.S.), a research team at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg found an optimization mechanism in CRISPR-Cas13, providing insights into the evolution of these systems. The results were recently published in The EMBO Journal.

In a groundbreaking advancement poised to transform genetic medicine, scientists have successfully harnessed CRISPR/Cas9 gene-editing technology to correct a common mutation responsible for Wilson disease, a debilitating inherited disorder. Utilizing patient-specific induced pluripotent stem cells (iPSCs), researchers have demonstrated an unprecedented level of precision in targeting and rectifying the H1069Q point mutation in the ATP7B […]

Scientists have taken an important step toward a gene therapy that could one day turn off the extra genetic material that causes Down syndrome (DS). Down syndrome is a genetic condition caused by an extra chromosome 21 (and consequently hundreds of triplicate genes) that leads to developmental and neurological issues. According to the Washington-based National Down Syndrome Society, approximately 1 in every 640 babies in the United States is born with DS. That makes it the most common chromosomal condition.

A study using tiny retinas grown in a lab has revealed how subtle changes in a key growth-controlling protein can lead to a condition causing serious eye defects from birth. The findings, published in the journal Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, shed new light on ocular coloboma, a rare congenital eye condition affecting about 1 in 5,000 births and responsible for roughly 10% of childhood blindness. Coloboma arises when a structure in the developing eye, the optic fissure, fails to close properly and often co-occurs with other tissue-fusion problems such as cleft lip and/or palate.

A research team has discovered an enhanced CRISPR gene-editing system that could enable targeted delivery inside the human body—a key step toward broader clinical use. Researchers identified a naturally occurring enzyme, Al3Cas12f, that is small enough to fit into adeno-associated virus vectors, a leading targeted delivery method for gene therapies. They then engineered an enhanced version that dramatically improved gene-editing performance in human cells.

In a groundbreaking development poised to reshape our understanding of insulin regulation and diabetes treatment, a team of researchers has identified critical proinsulin regulators using a sophisticated CRISPR-based screening approach combined with in vivo quantitative trait locus (QTL) mapping in mice. This innovative study, conducted by Lai, Keller, Zhang, and colleagues, and slated for publication […]

A groundbreaking advance in gene editing technology has emerged from the University of Texas at Austin, as researchers have engineered a novel CRISPR-based molecular tool that holds promise for direct therapeutic gene editing inside the human body. A collaborative effort involving scientists funded by the National Institutes of Health (NIH) and the biotech company Metagenomi […]

In a groundbreaking advance that promises to reshape the landscape of bioprinting, researchers have unveiled a novel methodology for rapid volumetric bioprinting (VBP) of pristine protein-based bioinks. This innovative approach leverages the inherent tyrosine groups in natural proteins such as silk, gelatin, and decellularized extracellular matrix (dECM) to generate complex, three-dimensional biological constructs swiftly and […]

In a groundbreaking advancement for agricultural biotechnology, a team of researchers from China has successfully harnessed the power of CRISPR/Cas9 cytosine base editing to generate a novel sweet maize variety, termed sh2isu1, in a single step. This leap forward signifies an innovative departure from conventional breeding methods that have long relied on natural mutations accumulated […]

In a groundbreaking advancement that could redefine therapeutic strategies for neurodegenerative disorders, researchers have harnessed the precision of CRISPR–Cas9 gene editing technology to engineer human pluripotent stem cells with unparalleled specificity aimed at combating Parkinson’s disease. Researchers from leading institutions have elucidated a novel method for reprogramming and correcting cellular anomalies implicated in Parkinson’s pathophysiology, […]

The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-associated genes.

Since 2017, a personalized immunotherapy called Chimeric Antigen Receptor, or CAR-T cell treatment, has worked wonders to treat patients with blood cancers such as leukemia. But when it comes to treating solid tumor cancers, such as lung, breast and kidney cancers that make up the bulk of these malignancies, this type of immune cell therapy has fallen short.

Cancer stem cells (CSCs) represent a formidable challenge in oncology due to their unique ability to self-renew, differentiate, and fuel tumor initiation, progression, metastasis, and therapy resistance. Despite decades of research, the intricate molecular mechanisms that govern the behavior of CSCs remain incompletely understood. Recently, non-coding RNAs, particularly long non-coding RNAs (lncRNAs), have emerged as […]

The unprecedented advancement of CRISPR/Cas genome editing technology has ushered in a transformative era for cellular and gene therapies, offering extraordinary precision in the correction, disruption, and regulation of genes implicated in myriad diseases. As these technologies advance from experimental stages to clinical realities, the necessity for comprehensive and rigorous non-clinical safety assessments has taken […]

Five people with beta thalassemia who had their blood stem cells genetically altered no longer require regular blood transfusions to stay healthy. Their Chinese-made treatment is likely to be cheaper, and perhaps safer and more ...

Improved gene editing process reactivates the fetal version of a hemoglobin gene.

In the ever-evolving landscape of cancer research, the discovery of novel therapeutic targets remains a paramount priority. Recently, a groundbreaking study has illuminated a previously uncharted domain within the oncogenic process, focusing on the role of long non-coding RNAs (lncRNAs) that drive tumor progression and their potential vulnerability to existing pharmacological agents. Utilizing advanced CRISPR […]

In heart failure, the heart can no longer supply the body with enough blood. The condition often develops over many years, for example, due to high blood pressure or other long-term strain on the heart muscle. At first, the heart tries to compensate for this extra workload by working harder, which causes it to enlarge. Over the long term, however, this adaptation leads to structural changes in the heart tissue, and the heart's pumping function progressively deteriorates. Until now, it has been largely unclear which processes occur in the heart muscle during this process and can be specifically targeted for treatment.

In a groundbreaking advance toward understanding the molecular underpinnings of myelodysplastic syndromes (MDS), researchers have generated the first base-resolution DNA methylome from hematopoietic stem cells (HSCs) of human MDS patients. This landmark study, published in the prestigious journal Immunity & Inflammation, uncovers how epigenetic dysregulation—particularly involving the TET2-GFI1 axis—shapes the initiation and progression of MDS […]

In a remarkable breakthrough that holds immense potential for environmental remediation, researchers at Nagoya University have unveiled a chemical strategy capable of activating native soil bacteria to degrade persistent and toxic aromatic pollutants like benzene and dioxins—without resorting to genetic modification. This innovative method leverages the natural enzymatic machinery of ubiquitous soil microbes, specifically cytochrome […]

Stem cell transplantation could be a rapid and effective way to restore hemoglobin production in individuals with the blood disorder β-thalassaemia. The treatment, presented in a phase 1 clinical trial, could reduce dependence on blood transfusions in some individuals with the disease in the future, although further trials are needed to confirm these findings.

Researchers at the Institute of Biomedical Engineering at the University of Toronto have demonstrated a new way to monitor transplanted stem-cell-derived heart cells using magnetic resonance imaging (MRI).

Organoids are miniature, simplified versions of an organ. Over the past two decades, scientists have developed them for the gut, lung, liver, mammary gland, brain, and more. Now, researchers at Yale School of Medicine (YSM) have organoid-ized the pineal gland, a small structure in the brain that regulates sleep patterns through its production of the hormone melatonin.

A gene-edited barley designed to cut livestock emissions and boost feed efficiency has become the first crop approved under the UK’s new pre...

An AI system unearthed a trove of CRISPR-like proteins in minutes instead of weeks or months. The post MIT Mined Bacteria for the Next CRISPR—and Found Hundreds of Potential New Tools appeared first on SingularityHub.

In the first of a new series of Keynote Webinars, Professor Rodolphe Barrangou, PhD (North Carolina State; EIC, The CRISPR Journal) offers a front-row perspective of the CRISPR revolution, the seminal advances, clinical highlights, and rising applications. The post CRISPR at 25: The Past, Present, and Future of Genome Editing appeared first on GEN - Genetic Engineering and Biotechnology News.

A New Milestone in Cardiovascular Research Do you know? The death caused by Cardiovascular diseases ranks one amongst the mortality rate by any disease. Though we have evolved in the health sciences and technology, it remains a matter of concern. To find a solution, Chinese researchers have taken a significant step forward in cardiovascular research. […] The post World-First Gene-Edited Pigs Could Revolutionize Cardiovascular Research appeared first on BioTecNika.

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In a preclinical animal study, implantation of lab-grown esophageal grafts restored swallowing, offering hope for infants with long-gap esophageal atresia.

The Information: Source: Anthropic has acquired Coefficient Bio, which was developing a platform that enables AI to run biotech tasks such as planning drug research, for ~$400M  —  Anthropic has acquired AI biotech startup Coefficient Bio for roughly $400 million, according to a person with knowledge of the deal.

Scientists at Rothamsted Research have successfully developed wheat with dramatically reduced levels of asparagine, without affecting yield, using gene editing techniques, offering a promising route to safer food production and improved regulatory compliance. Results from two years of field trials demonstrate that wheat produced using CRISPR genome editing can significantly lower concentrations of free asparagine—an amino acid that converts into acrylamide, a toxic and probably carcinogenic compound formed during everyday baking, frying, and toasting.

VML is unveiling the world's first T-Rex leather product in Amsterdam, marking the beginning of a manufacturing revolution.

New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease, a genetic blood disorder with few curative options.

A revolutionary breakthrough in the treatment of severe sickle cell disease (SCD) has been reported from the latest data emerging from the multicenter RUBY Trial, producing highly promising outcomes that could redefine therapeutic strategies for this challenging genetic blood disorder. The findings, published in the prestigious New England Journal of Medicine, demonstrate unprecedented clinical success […]

New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease, a genetic blood disorder with few curative options. After research conducted as part of the multicenter RUBY Trial, researchers have published their latest findings in the New England Journal of Medicine. Remarkably, 27 out of 28 patients did not have any painful sickle cell crises after treatment, achieving what physicians call a "functional cure."

Last year's successful treatment of an infant known as Baby KJ encouraged scientists to try again. But now, five weeks after the FDA outlined its plans to make such individualized genetic medicines more accessible, researchers ...

Mississippi has become the first U.S. state to ban cell‑cultured dairy products. The law follows a 2024 measure banning lab‑grown meat in the state.

Why are some people unable to hear from birth, even though their inner ear appears intact? One possible cause lies in the so-called OTOF gene. It plays a central role in transmitting sound signals from the hair cells to the auditory nerve. Without this function, acoustic information does not reach the brain.

The scientists who treated Baby KJ say the FDA's strict standards will make it much harder to create bespoke gene editing for others.

The authorship of this article by Attar and colleagues (BMJ 2025;391:e083382, doi:10.1136/bmj-2024-083382, published 29 October 2025)1 has been corrected to remove Anthony Mathur and Sheik Dowlut.What happened after publicationAfter publication of the original article, Anthony Mathur and Sheik Dowlut, who were listed as authors of the study, wrote to the journal to say that they were not authors. The editors published an expression of concern2 due to several concerns, including authorship.On investigation, it transpired that Mathur and Dowlut’s only contribution to the work was to provide feedback on the manuscript before its submission to The BMJ. Mathur and Dowlut asked Attar by email before submission to remove them from the list of authors, but this was not done. Although Mathur and Dowlut were subsequently included among the recipients of emails sent by the journal during the submission process to all the listed authors, which identified them as authors of the...

This article by Attar and colleagues (BMJ 2025;391:e083382, doi:10.1136/bmj-2024-083382, published 29 October 2025)1 is retracted by the journal.What happened after publicationThe journal was alerted to issues in this content regarding the design, conduct, or reporting of the work.2 The editors published an expression of concern3 due to concerns that the trial might have breached accepted trial practices and/or be unreliable. The authors cooperated with the journal and provided additional information; they have also responded on PubPeer. The journal reviewed the issues, including the following points below.Concerns regarding the reliability of the trial and the integrity of the reported dataThe issues included apparent recruitment outside of the inclusion criteria, including those over 65 years old; discrepancy in the number of participants enrolled; and data irregularities, such as unusual patterns in the data (including improbable values and/or repeated numbers) and mismatched and

Two Northeastern University researchers want to make life better for people who've experienced serious physical trauma, the kind caused by bad car accidents or from injuries sustained during wartime; such procedures are crucial. That process takes on an added layer of complication when damage occurs to the nervous system.

Scientists at the University of Michigan have pioneered a groundbreaking method to deliver gene therapies using protein-coated nanoparticles that promise enhanced safety and efficacy compared to traditional viral vectors. This innovation could transform treatment paradigms for cancer and genetic diseases by mitigating risks associated with viral-based gene delivery systems, which despite their successes, remain plagued […]

In a demonstration that could help pave the way for gene therapies with fewer side effects, several human cell types have been genetically modified with protein nanoparticles designed at University of Michigan Engineering and Michigan Medicine. Gene therapy has been enormously successful for treating disorders of the blood, including sickle cell disease and leukemia. However, using a virus as a vector for treatment can create unwanted side effects, such as secondary cancers and immune system overreactions. With the nanoparticles, the research team aims to develop a safer method for delivering gene therapies.

In a groundbreaking advancement that could reshape the landscape of genetic medicine, researchers have announced the successful completion of the first-ever clinical trial utilizing nuclease-free, homologous recombination-dependent gene editing in pediatric patients. This pioneering study, led by a team including Bedoyan, Morgan, and Sun, has targeted methylmalonic acidemia (MMA), a severe metabolic disorder, marking a […]

Scientists led by Botond Roska at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) and collaborators have identified genetic pathways and compounds capable of protecting cone photoreceptors from the degeneration that underlies conditions like age-related macular degeneration.

Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-linked chromatin changes and later amplifies tumour outgrowth after oncogenic mutation.

This GEN Live show will focus on new areas of stem cell research, including aging. It will bring together a panel of leading experts to unpack the latest advances and ongoing challenges in stem cells. The post Stem Cells at the Frontier: Breakthroughs, Barriers, and What’s Next appeared first on GEN - Genetic Engineering and Biotechnology News.

While Minnesota tries to make sure cell-cultured food is labeled as such, South Dakota has passed a moratorium on any lab-grown meat in the state.

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing systems that merely find and cut DNA. The research includes two complementary studies, one examining the biological function of the system and the other revealing the molecular mechanism that enables it.

Researchers have identified many contributing issues leading to the characteristic loss of muscle mass and strength that takes place with age. Arguably the central problems are (a) the disruptions of cell behavior caused by chronic inflammation, (b) damage to neuromuscular junctions, depriving muscle tissue of signals it relies upon for normal maintenance to take place, and (c) loss of muscle stem cell activity, and thus a reduced supply of somatic muscle cells to replace losses. These central problems likely interact with one another, but in principle could be addressed distinctly to produce benefits in patients. Past studies have shown, rather convincingly, that muscle stem cells in older individuals retain their function when moved from an old environment to a young environment. The problem is not […]

Scientists from Great Ormond Street Hospital (GOSH) and University College London (UCL) have created the first lab‑grown esophagus - the food pipe - shown to safely replace a full section of the organ and restore normal function, including swallowing, in a growing animal without the need for immunosuppression.

Animal studies often fail to predict human tissue responses to new drugs or newly developed therapies. Besides generating tremendous costs for clinical studies, it also raises significant ethical concerns. Therefore, novel approaches to mimicking natural human environments like vascular system growth control, are broadly developed to deliver a reproducible model to test novel drugs.

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) have developed a revolutionary new method to improve compact gene-editing tools known as base editors, which enable smaller, more precise DNA correction tools that may be safer for future gene therapies.

In this edition of STAT Health Tech: How Apple Watch is being used in a clinical trial for a Parkinson's drug, and more

Each year, thousands of people in the U.S. die waiting for donated organs. A new book shares how organs from other species could change that.

Explore how CRISPR gene editing is transforming genetic disease treatment, uncovering breakthroughs, safety advances, and the future possibilities of curing inherited disorders through DNA repair.

The Norwich-based agbiotech company launched the first new commercial banana varieties in more than 75 years in 2025. Now it has to build enough supply to meet demand. The world’s favourite fruit is in serious trouble. Panama Disease Tropical Race 4, a fungal pathogen that travels in soil and water and leaves no cure in […] This story continues at The Next Web

Mechanistic studies suggest the amino acid cocktail enhances a clathrin‑independent, carrier‑mediated endocytic pathway, increasing the efficiency with which cells internalize LNPs. The post Amino Acid Cocktail Supercharges LNP Delivery for mRNA and CRISPR Therapies appeared first on GEN - Genetic Engineering and Biotechnology News.

"2025 proved that our technology delivers, not in the distant future, but right now," says CEO Gilad Gershon. The post Tropic bags $105m to scale gene-edited bananas, deploy TR4 resistant bananas in 2027 appeared first on AgFunderNews.

Site-specific insertion of gene-sized DNA fragments remains an unmet need in the field of genome editing. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombination in bacteria by using a bispecific RNA guide (...

Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution.

In an extraordinary advance poised to redefine regenerative medicine, a collaborative team from the University of Hong Kong’s LKS Faculty of Medicine and Toronto’s Lunenfeld-Tanenbaum Research Institute has engineered a new class of human pluripotent stem cells capable of evading immune rejection with unprecedented precision and safety. This breakthrough, published recently in Stem Cell Reports, […]

A handful of biotech startups have recently taken an increasingly popular route of financing: extending existing rounds rather than taking on a whole new fundraising campaign. If "money is like oxygen for biotechs," in the ...

Nanogel integrated spheroids increase cell retention and repair injured swallowing muscles.

In a breakthrough that could revolutionize treatments for swallowing disorders, a collaborative research team from Kyoto University in Japan and McGill University in Canada has developed an innovative approach to stem cell therapy, utilizing biodegradable nanogels integrated into three-dimensional stem cell spheroids. The technique addresses a critical hurdle in regenerative medicine for muscle repair — […]

In a groundbreaking advancement poised to revolutionize the field of therapeutic delivery, scientists at Biohub have unveiled a remarkably straightforward yet powerful strategy to dramatically enhance the efficacy of lipid nanoparticle (LNP) mediated mRNA and gene editing therapies. These nanoparticles, long celebrated as the pivotal delivery vehicles behind the global rollout of COVID-19 mRNA vaccines, […]

CRISPR Therapeutics (NASDAQ:CRSP) is one of the best stocks for 20 years. On February 12, CRISPR Therapeutics announced its financial results for 2025, highlighting a period of significant commercial and clinical growth. The company’s flagship gene-editing therapy, CASGEVY, generated $116 million in total revenue for the year, with $54 million occurring in Q4 alone. This […]

Swallowing is a fundamental human function that supports nutrition and communication. Damage to swallowing muscles can reduce quality of life and even lead to aspiration pneumonia or malnutrition. Many patients suffer from swallowing difficulties after being treated for head or neck cancer, and swallowing disorders are also common in older adults, yet effective therapies have been limited.

Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution. Researchers are racing to use them to ferry therapeutic mRNA into cells for cancer therapies and treatments for inflammatory diseases, as well as delivering CRISPR constructs that can correct disease-causing gene mutations.

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